Recombinant Rat Fractalkine (FKN)
Code | Size | Price |
---|
LEI-F1023-25ug | 25 ug | £489.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rat
Regulatory Status: RUO
Shipping:
Ambient
Storage:
This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions.
Further Information
Format:
This recombinant protein was 0.2 um filtered and lyophilized from modified Dulbecco?s phosphate buffered saline (1X PBS) pH 7.2 ? 7.3 with no calcium, magnesium, or preservatives.
Formulation:
This recombinant protein was 0.2 um filtered and lyophilized from modified Dulbecco?s phosphate buffered saline (1X PBS) pH 7.2 ? 7.3 with no calcium, magnesium, or preservatives.
Long Description:
Fractalkine (FKN) is a transmembrane mucin-chemokine hybrid molecule expressed on activated endothelium1 that mediates attachment and firm adhesion of T cells, monocytes and NK cells.2 FKN plays an important proinflammatory role in rheumatoid arthritis (RA) pathogenesis as characterized by induction of synovial angiogenesis, chemotaxis, activation of monocytes and T cells as well as the stimulation of proliferation and synthesis of matrix degrading enzymes (matrix metalloproteinases, MMP) in synovial fibroblasts. Fractalkine thus may represent a novel target molecule for therapeutic intervention in RA.3 FKN is also an essential biomarker for predicting the prognosis of patients with colorectal cancer (CRC).4
NCBI Gene:
89808
Purity:
>97% by SDS-PAGE and analyzed by silver stain.
Target:
Fractalkine
References
1. Block, ML. et al. (2011) Environ Health Perspect.119(8):1149-55. doi: 10.1289/ehp.1002986. PubMed
2. Patel, DD et al. (1998) J Exp Med. 188: 1413
3. Hwang, ST et al. (1999) Eur J Immunol. 29: 2551
4. Muller, GA et al. (2008) Z Rheumatol. 67: 424
5. Mori, M et al. (2005) Int J Oncol. 26: 41