Anti-Human TAB1
| Code | Size | Price |
|---|
| LEI-T357-20ug | 20 ug | £199.00 |
Quantity:
| LEI-T357-0.1mg | 0.1 mg | £591.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Application: Western Blot (WB)
Shipping:
Ambient
Storage:
This polyclonal antibody is stable for at least one week when stored at 2-8°C. For long term storage aliquot in working volumes without diluting and store at -20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.
Further Information
Concentration:
0.5 mg/ml
Conjugate/Tag/Label:
Purified No Carrier Protein
Format:
This polyclonal antibody is formulated in phosphate buffered saline (PBS) pH 7.4 containing 0.02% sodium azide as a preservative.
Formulation:
This polyclonal antibody is formulated in phosphate buffered saline (PBS) pH 7.4 containing 0.02% sodium azide as a preservative.
Immunogen:
PN:T362
Long Description:
TAB1 was identified as a regulator of the MAP kinase kinase kinase TAK1/MAP3K7 (1), which is known to mediate various intracellular signaling pathways, such as those induced by TGF-β and members of the Toll-IL-1R (TIR) superfamily (2), thus acting as an intermediate in both proliferative and innate and adaptive immune responses (3). This protein, together with either TAB2 or TAB3, activates TAK1 kinase in response to upstream signals (4,5). It has been shown that the C-terminal portion of TAB1 is sufficient for binding and activation of TAK1, while a portion of the N-terminus acts as a dominant-negative inhibitor of TGF-β, demonstrating how this protein can function as a mediator between TGF-β receptors and TAK1 (6).
Target:
TAB1
References
1. Shirakabe, K. et al. (1996) Science 272:1179-82. 2. Takeshige, K. et al. (2000) FEBS Lett. 467:160-4. 3. Akira, S. and Takeda, K. (2004) Nat. Rev.Immunol. 4:499-511. 4. Qian, Y. et al. (2002) Mol. Cell Biol.22:7158-67. 5. Cohen, P. et al. (2004) Biochem J. 378:27-34. 6. Ninomiya-Tsuji, J. et al. (2003) Biochem. Biophys. Res. Commun. 307:3327.
Related Products
| Product Name | Product Code | Supplier | TAB1 Blocking Peptide | LEI-T362 | Leinco Technologies | Summary Details | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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