Recombinant Mouse Noggin (SYM1)
| Code | Size | Price |
|---|
| LEI-N179-25ug | 25 ug | £614.00 |
Quantity:
| LEI-N179-100ug | 100 ug | £1,308.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Mouse
Regulatory Status: RUO
Shipping:
Ambient
Storage:
This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions.
Further Information
Format:
This recombinant protein was 0.2 um filtered and lyophilized from modified Dulbecco?s phosphate buffered saline (1X PBS) pH 7.2 ? 7.3 with no calcium, magnesium, or preservatives.
Formulation:
This recombinant protein was 0.2 um filtered and lyophilized from modified Dulbecco?s phosphate buffered saline (1X PBS) pH 7.2 ? 7.3 with no calcium, magnesium, or preservatives.
Long Description:
Noggin, also called SYM1, is a secreted glycoprotein and belongs to a group of diffusible proteins which bind to ligands of the TGF-β family. Noggin has a complex pattern of expression during embryogenesis and is expressed in the central nervous system, as well as in several peripheral tissues such as lung, skeletal muscle and skin in adult (1-2). It was originally identified as a BMP-4 antagonist whose action is critical for proper formation of the head and other dorsal structures. Consequently, Noggin has been shown to modulate the activities of other BMPs, as well as, chordin and follistatin (3). Noggin plays a crucial role in bone development, joint formation, and neural tube fusion and can be used as a tool to differentiate human embryonic stem cells into neural precursor cells. Targeted deletion of Noggin in mice results in prenatal death and recessive phenotype displaying a severely malformed skeletal system (4). Conversely, transgenic mice over-expressing Noggin in mature osteoblasts display impaired osteoblastic differentiation, reduced bone formation, and severe osteoporosis.
NCBI Gene:
18121
Purity:
>90% by SDS-PAGE and analyzed by silver stain.
Target:
Noggin
References
1. Valenzuela, DM. et al. (1995) J. Neurosci. 15:60772. Brunet, LJ. et al. (1998) Science 280:14553. Nifuji, A. et al. (1999) J. Bone Mineral Res. 14:20574. Stottmann, RW. et al. (2006) Dev. Biol. 295:647
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