Recombinant Mouse PDGF-BB
| Code | Size | Price |
|---|
| LEI-P243-10ug | 10 ug | £307.00 |
Quantity:
| LEI-P243-100ug | 100 ug | £694.00 |
Quantity:
| LEI-P243-500ug | 500 ug | £3,072.00 |
Quantity:
| LEI-P243-1mg | 1 mg | £5,063.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Mouse
Regulatory Status: RUO
Shipping:
Ambient
Storage:
The lyophilized protein should be stored desiccated at -20°C. The reconstituted protein can be stored for at least one week at 4°C. For long-term storage of the reconstituted protein aliquot into working volumes and store at -20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.
Further Information
Format:
This protein was 0.2 um filtered and lyophilized from Sodium Citrate, pH 3.0.
Formulation:
This protein was 0.2 um filtered and lyophilized from Sodium Citrate, pH 3.0.
Long Description:
Platelet-derived growth factor-BB homodimers (PDGF-BB) activates all combinations of PDGF receptor subunits, whereas PDGF-AA acts specifically on PDGFR alpha.1 This constitutes a positive feed-back mechanism, which, for example, could serve to potentiate autocrine stimulation of growth.2 PDGF-BB plays an important role in the cellular metabolism of vascular wall by regulating the rate of macrophage-colony stimulating factor (M-CSF) production in vascular smooth muscle cells.3 PDGF-BB is also a potent wound-healing hormones that accelerate incisional repair.4 PDGF-BB is associated with excessive cell migration, proliferation and many growth-related diseases.5 It may be a new prognostic indicator for patients with colorectal cancer.6 PDGF-BB may also induce coronary atherosclerotic disease formation by stimulating coronary artery smooth muscle cell (CASMC) migration and proliferation through agent-specific regulation of oxidative status and utilization of different signal transduction pathways.5
NCBI Gene:
18591
Purity:
>98% by SDS Page and HPLC
Target:
PDGF-BB
References
1. Pfeilschifter, J. et al. (2005) Am Society of Nephrol. 10: 16812. Claesson-Welsh, L. et al. (1991) J Biol Chem. 266: 211383. Yamada, N. et al. (1992) J Biol Chem. 267: 154554. Mustoe, TA. et al. (1991) J Lab Clin Med. 117: 3735. Bayraktutan, U. et al. (2008) J Mol Cell Cardiol. 45: 1986. Mori, M. et al. (2008) Ann Surg Oncol. 15: 2129
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