Recombinant Human Secreted Frizzled Related Protein-1
| Code | Size | Price |
|---|
| LEI-S563-5ug | 5 ug | £372.00 |
Quantity:
| LEI-S563-20ug | 20 ug | £532.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Human
Regulatory Status: RUO
Shipping:
Ambient
Storage:
This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions.
Further Information
Long Description:
Secreted Frizzled Related Protein-1 also known as SFRP1 is a member of the secreted frizzled-related proteins (sFRPs) which are glycoproteins that are negative regulators of the Wnt pathway.1 SFRP1 is strongly expressed throughout embryonic development in different vertebrate species.2 It regulates cell proliferation, differentiation and apoptosis and negatively regulates bone formation.3 SFRP1 expression might be useful as a novel prognostic marker in early stage breast cancer.4 SFRP 1 is also a candidate tumor suppressor gene for lung cancer.5
Purity:
>97% by SDS Page and HPLC
Target:
sFRP-1
References
1. Bodine, PV. et al. (2007) J Cell Biochem. 102: 15192. Bovolenta, P. et al. (2004) Mech Dev. 121: 6873. Lian, JB. et al. (2008) J Cell Physiol. 217: 1134. Dahl, E. et al. (2004) Int J Oncol. 25: 6415. Sekido, Y. et al. (2005) Oncogene 24: 6323