Leinco Technologies

Recombinant Human MMP-1

Product Code:
 
LEI-M1250
Product Group:
 
Recombinant Proteins
Host Type:
 
Human
Regulatory Status:
 
RUO
Shipping:
 
Dry Ice
Storage:
 
Working aliquots of this recombinant protein solution are stable for up to six months at -20°C to -70°C in a manual defrost freezer. Upon thawing in the presence of a carrier protein this recombinant protein can be stored at -20°C to -70°C for three months without detectable loss of activity. For long-term storage aliquot and freeze at -20°C to -70°C in a manual defrost freezer. Avoid repeated freeze thaw cycles.
 

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LEI-M1250-10ug10 ug£642.00
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This product comes from: US.
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Further Information

Format:
This recombinant protein was 0.2 um filtered and is supplied in a solution of sodium chloride (NaCl), calcium chloride (CaCl2), MES and Brij-35.
Formulation:
This recombinant protein was 0.2 um filtered and is supplied in a solution of sodium chloride (NaCl), calcium chloride (CaCl2), MES and Brij-35.
Long Description:
Matrix metallopeptidase 1 (interstitial collagenase), also known as MMP1 is an enzyme involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. MMP-1 is the only enzyme able to initiate breakdown of the interstitial collagens, collagen type 1, collagen type 2, and collagen type 3.1,2 MMP-1 plays an important role in diverse physiologic processes such as development, tissue morphogenesis, and wound repair. Expression of MMP-1 is a prognostic marker for hematogenous metastasis of colorectal cancer.3
NCBI Gene:
4312
Purity:
>95% by SDS-PAGE and analyzed by silver stain.
Target:
MMP-1

References

1. Brinckerhoff et al. (1987) Oncology 64: 337 2. Saffarian et al. (2004) Science 306: 108 3. Sunami E. et al. (1987) Oncologist 5: 108