Recombinant Human ACE-2 (His-tag)
| Code | Size | Price |
|---|
| LEI-A352-10ug | 10 ug | £614.00 |
Quantity:
| LEI-A352-100ug | 100 ug | £2,207.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Human
Regulatory Status: RUO
Shipping:
Polar Packs
Storage:
Working aliquots of this recombinant protein solution are stable for up to six months at -20°C to -70°C in a manual defrost freezer. Upon thawing in the presence of a carrier protein this recombinant protein can be stored at -20° to -70°C for three months without detectable loss of activity. For long-term storage aliquot and freeze at -20°C to -70°C in a manual defrost freezer. Avoid repeated freeze thaw cycles.
Further Information
Format:
This recombinant protein was 0.2 um filtered and is supplied in a solution of sodium chloride (NaCl), zinc chloride (ZnCl2), tris and glycerol.
Formulation:
This recombinant protein was 0.2 um filtered and is supplied in a solution of sodium chloride (NaCl), zinc chloride (ZnCl2), tris and glycerol.
Long Description:
Angiotensin I converting enzyme 2 (ACE2) is an exopeptidase that catalyses the conversion of angiotensin I to the nonapeptide angiotensin[1-9].1 ,or the conversion of angiotensin II to angiotensin 1-7.2 ACE 2 has direct effects on cardiac function2, and is expressed predominantly in vascular endothelial cells of the heart and the kidneys.3 ACE2 plays a regulatory role in lung pathophysiology, including pulmonary fibrosis and acute lung disease. Activation of ACE2 by a small molecule can be a therapeutically relevant approach for treating and controlling Pulmonary Hypertension (PH).4 ACE2 may also have clinical potential as a novel molecular target for the treatment of pancreatic ductal adenocarcinoma (PDAC).5
NCBI Gene:
59272
Purity:
>90% by SDS-PAGE and analyzed by silver stain.
Target:
ACE-2
References
1. Acton, S. et al. (2000) Circ Res. 87: E1
2. Gamliel-Lazarovich, A. et al. (2007) Cardiovasc Res. 73: 463
3. Nabel, EG. et al. (2000) N Engl J Med. 347: 1795
4. Raizada, MK. et al. (2009) Am J Respir Crit Care Med. 179(11):1048-54.
5. Yuan, Y. et al. (2009) Tohoku J Exp Med. 217: 123