Recombinant Human DAN
| Code | Size | Price |
|---|
| LEI-D341-50ug | 50 ug | £614.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Human
Regulatory Status: RUO
Shipping:
Ambient
Storage:
This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions.
Further Information
Long Description:
DAN is a secreted glycoprotein related to Xenopus laevis cerberus. It is being referred to also as DAND1 [DAN domain family member 1]. The gene has been described also as NO3 gene, which shows tumor suppressor activity in cells transformed by the src oncogene.1 DAN belongs to a gene family, termed CAN family, that includes the head-inducing factor Gremlin, Cerberus, PRDC.2 DAN and several other members of the can family act as antagonists of BMP and appear to block BMP signaling by preventing bone morphogenetic proteins from interacting with their receptors. DAN has recently been demonstrated to have a tumor-suppressive activity in vitro and may have an important role in regulation of the entry of cells into the S phase.3
NCBI Gene:
4681
Purity:
>95% by SDS-PAGE and analyzed by silver stain.
Target:
DAN
References
1. Ozaki, T. and Sakiyama, S. (1993) Proc. Natl Acad. Sci. USA 90:2593-2597
2. Rossant, J. et al. (1999) Dev Biol. 209(1):98-110.
3. Sakiyama S. et al. (1995) Biochem Biophys Res Commun. 216(1):209-15.
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