Leinco Technologies

Recombinant Mouse IL-3 Rα

Product Code:
 
LEI-I-598
Product Group:
 
Recombinant Proteins
Host Type:
 
Mouse
Regulatory Status:
 
RUO
Shipping:
 
Ambient
Storage:
 
This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions.
 

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LEI-I-598-100ug100 ug£614.00
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  • Further Information
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Further Information

Long Description:
IL-3 R alpha binds IL-3 with relatively low affinity. In the presence of IL-3 R beta, however, IL-3 R alpha has a much higher affinity for IL-3. It is not clear how signal transduction occurs following IL-3 binding. The IL-3 R alpha chain has a very short intracellular domain while the IL-3 R beta chain has a very large cytoplasmic domain. Recent studies suggest that formation of IL-3 R beta-beta homodimers initiates signaling events. The IL-3 R beta chain is also shared by the receptors for IL-5 and GM-CSF. Cells known to express IL-3 receptors include hematopoietic progenitors, epithelial cells, double negative T cells, mast cells, basophils and blood monocytes.
NCBI Gene:
16188
Purity:
>90% by SDS-PAGE and analyzed by silver stain.
Target:
IL-3 R alpha

References

1. Garnache-Ottou, F. et al. (2015) Haematologica. 100(2):223-302. Phillips, GL. et al. (2000) Leukemia 14: 1777