Recombinant Human SIGIRR
| Code | Size | Price |
|---|
| LEI-S575-100ug | 100 ug | £648.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Human
Regulatory Status: RUO
Shipping:
Ambient
Storage:
This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions.
Further Information
Long Description:
Single immunoglobulin and toll-interleukin 1 receptor (TIR) domain, also known as SIGIRR is a member of the IL-1 receptor family.1 It acts as a negative regulator of interleukin (IL)-1 and lipopolysaccharide (LPS) signaling.2 It also plays a critical role in gut homeostasis, intestinal inflammation, and colitis-associated tumorigenesis by maintaining the microbial tolerance of the colonic epithelium.3
NCBI Gene:
59307
Purity:
>90% by SDS-PAGE and analyzed by silver stain.
Target:
SIGIRR
References
1. Mantovani, A.et al. (2003) Eur Cytokine Netw. 14: 2112. Li, X. et al. (2005) J Biol chem. 280: 252333. Li, X et al. (2007) Immunity 26: 461
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