Anti-Human IL-5 (Clone14611)
| Code | Size | Price |
|---|
| LEI-I-632-25ug | 25 ug | £375.00 |
Quantity:
| LEI-I-632-100ug | 100 ug | £659.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Mouse
Antibody Isotype: IgG1
Antibody Clonality: Monoclonal
Antibody Clone: 14611
Regulatory Status: RUO
Target Species: Human
Application: Neutralisation
Shipping:
Ambient
Storage:
The lyophilized antibody can be stored desiccated at -20°C to -70°C for up to twelve months. The reconstituted antibody can be stored for at least four weeks at 2-8°C. For long-term storage of the reconstituted antibody aseptically aliquot into working volumes and store at -20°C to -70°C in a manual defrost freezer. Avoid repeated freeze thaw cycles. No detectable loss of activity was observed after six months.
Further Information
Conjugate/Tag/Label:
Purified No Carrier Protein
Format:
This monoclonal antibody has been 0.2 um filtered in 20 mM Tris and 300 mM NaCl, pH 8.0 with concentration of 0.833 mg/mL and no calcium, magnesium or preservatives present.
Formulation:
This monoclonal antibody has been 0.2 um filtered in 20 mM Tris and 300 mM NaCl, pH 8.0 with concentration of 0.833 mg/mL and no calcium, magnesium or preservatives present.
Immunogen:
Purified Recombinant Human IL-5 (Accession # P05113)
Long Description:
IL-5 is a 26 kD TH2 cytokine and a homodimeric glycoprotein that is part of the hematopoietic family. IL-5 stimulates B cell growth as well as increases Ig secretion. It is the main factor that promotes the terminal differentiation of eosinophil progenitors and enhances the effector capacity of mature eosinophils. IL-5 is a major regulator of eosinophil accumulation in tissues. In fact, in Hodgkin lymphoma, the characteristically observed eosinophilia is suspected to result from an increased production of IL-5. IL-5 may also be the cause of several allergic diseases including asthma, where it is thought that eosinophils have a significant role in the disease pathology. There are several mAbs currently in use that target IL-5 for the treatment of severe eosinophilic asthma.
Target:
IL-5
References
1. Capron, M. et al. (1994) J Exp Med 179: 703
2. Graber, P. et al. (1993) Nature 363: 172
3. Inokuma, S. et al. (2005) Int Arch Allergy Immunol 1: 55
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