Anti-Human CD80 - PE
| Code | Size | Price |
|---|
| LEI-C1535-25tests | 25 tests | £284.00 |
Quantity:
| LEI-C1535-100tests | 100 tests | £500.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Mouse
Antibody Isotype: IgG1
Antibody Clonality: Monoclonal
Antibody Clone: 37711
Regulatory Status: RUO
Target Species: Human
Application: Flow Cytometry
Shipping:
2-8°C
Storage:
This R-phycoerythrin (R-PE) conjugate is stable for at least twelve months when stored at 2-8°C protected from light. Do not freeze.
Further Information
Antigen Distribution:
CD80 is expressed on activated B cells, monocytes/macrophages, and dendritic cells.
Conjugate/Tag/Label:
R-phycoerythrin (PE)
Format:
This monoclonal antibody is conjugated to R-phycoerythrin (R-PE) and formulated in modified Dulbecco's phosphate buffered saline (1X PBS) pH 7.2 - 7.3 containing 0.1% sodium azide as a preservative.
Formulation:
This monoclonal antibody is conjugated to R-phycoerythrin (R-PE) and formulated in modified Dulbecco's phosphate buffered saline (1X PBS) pH 7.2 - 7.3 containing 0.1% sodium azide as a preservative.
Long Description:
CD80 is a highly glycosylated 60 kD protein that is part of the Ig superfamily and is significantly involved in immune cell activation in response to pathogens. CD80 is closely related to, and works in tandem with CD86 (B7-2) to prime T- cells. CD80 binds to CTLA-4 to deliver an inhibitory signal to T cells. The ligation of CD28 on T cells with CD80 and CD86 on APCs co-stimulates T cells resulting in enhanced cell activation, proliferation, and cytokine production. It is thought that CD80 interacts with a ligand on Natural Killer cells, activating the Natural Killer cell-mediated cell death of the CD80 carrier. The activation of Natural Killer cell-mediated death via CD80 interactions has potential as a possible cancer immunotherapy through the induction of CD80 expression on tumor cells.
NCBI Gene:
941
Target:
CD80