Anti-Human GFRα-2
| Code | Size | Price |
|---|
| LEI-G683-25ug | 25 ug | £375.00 |
Quantity:
| LEI-G683-100ug | 100 ug | £659.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Caprine (Goat)
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Applications:
- Blocking
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Immunohistochemistry- Paraffin Embedded (IHC-P)
- Western Blot (WB)
Shipping:
Ambient
Storage:
The lyophilized antigen affinity purified polyclonal antibody can be stored desiccated at -20°C to -70°C for twelve months from date of receipt. The reconstituted antibody can be stored for at least four weeks at 2-8°C. For long-term storage of the reconstituted antibody aseptically aliquot into working volumes and store at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. No detectable loss of activity was observed after six months.
Further Information
Conjugate/Tag/Label:
Antigen Affinity Purified
Format:
This antigen affinity purified polyclonal antibody has been 0.2 um filtered and lyophilized from modified Dulbecco?s phosphate buffered saline (1X PBS) pH 7.2 ? 7.3 containing 5.0% w/v trehalose with no calcium, magnesium, or preservatives present.
Formulation:
This antigen affinity purified polyclonal antibody has been 0.2 um filtered and lyophilized from modified Dulbecco?s phosphate buffered saline (1X PBS) pH 7.2 ? 7.3 containing 5.0% w/v trehalose with no calcium, magnesium, or preservatives present.
Immunogen:
NS0 - Derived Recombinant Human GFR α-2 Extracellular Domain
Long Description:
Glial cell line-derived neurotrophic factor family receptor alpha-2, also known as GFRA2, is the cognate co-receptor for the neurotrophic factor neurturin that is selectively expressed by isolectin B(4) (IB 4)-binding nociceptive sensory neurons.1 GFRA2 is required for the development of the myenteric nerve plexus and is an excellent candidate gene for Hirschsprung disease (HSCR).2 GFRalpha2 signaling is also needed for development of the parasympathetic islet innervation that is critical for vagally induced hormone secretion.3
NCBI Gene:
2675
Target:
GFR alpha-2
References
1. Lewin, GR. et al. (2002) J Physiol. 545: 43
2. Mulligan, LM. et al. (2001) Human Genetics 108: 409
3. Herzig, KH. et al. (2005) Diabetes 54: 1324
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