Recombinant Human Bim L
| Code | Size | Price |
|---|
| LEI-B621-50ug | 50 ug | £630.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Human
Regulatory Status: RUO
Shipping:
Dry Ice
Storage:
This protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic opening this protein may be stored at 2°C to 8°C for (1) one week. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions.
Further Information
Format:
This recombinant protein was 0.2um filtered and is supplied in a solution of 20mM HEPES-KOH, 1mM DTT, 100mM KCL and 2% Glycerol at a pH of 8.0.
Formulation:
This recombinant protein was 0.2um filtered and is supplied in a solution of 20mM HEPES-KOH, 1mM DTT, 100mM KCL and 2% Glycerol at a pH of 8.0.
Long Description:
BimL a pro-apoptotic member of the BCL-2 protein family is also called Bod, BAM, or B2L11. This protein is one of several splice variants and interacts with other members of the BCL-2 protein family, including BCL2, BCL2L1/BCL-X(L), and MCL1, and act as an apoptotic activator. Its expression can be induced by nerve growth factor (NGF), as well as by the forkhead transcription factor FKHR-L1, which suggests a role in neuronal and lymphocyte apoptosis. Transgenic studies in the mouse suggested that this protein functions as an essential initiator of the apoptosis in thymocyte-negative selection by binding and inhibiting the activity of anti-apoptoticBcl-2 family members, thereby inducing the release of cytochrome c from mitochondria.
NCBI Gene:
10018
Purity:
>95% by SDS-PAGE and analyzed by silver stain.
Target:
BIM Long