Recombinant Human EGF R
| Code | Size | Price |
|---|
| LEI-E308-2ug | 2 ug | £284.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Human
Regulatory Status: RUO
Shipping:
Ambient
Storage:
This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions.
Further Information
Format:
This recombinant protein was 0.2 um filtered and lyophilized from modified Dulbecco?s phosphate buffered saline (1X PBS) with BSA as a carrier protein. pH 7.2 ? 7.3 with BSA.
Formulation:
This recombinant protein was 0.2 um filtered and lyophilized from modified Dulbecco?s phosphate buffered saline (1X PBS) with BSA as a carrier protein. pH 7.2 ? 7.3 with BSA.
Long Description:
EGF Receptor (EGFR, ErbB1) is a transmembrane protein that exerts tyrosine kinase activity upon ligand induced activation. Those ligands include EGF, TGF-alpha, HB-EGF, BTC, Amphiregulin, Epiregulin, and Epigen (1). When the intrinsic kinase is activated, EGFR tyrosyl-phosphorylates itself and numerous intermediary effector molecules, including closely-related c-erbB receptor family members. This initiates a signaling cascade which includes dimerization and internalization, tyrosine phosphorylation, DNA synthesis of target genes, and cell proliferation (2). In addition to being implicated in organ morphogenesis, maintenance and repair, upregulated EGFR signaling has been correlated in a wide variety of tumors with progression to invasion and metastasis. Thus, EGFR and its downstream signaling molecules are targets for therapeutic interventions in wound repair and cancer (3).
NCBI Gene:
13649
Purity:
>95% by SDS-PAGE and analyzed by silver stain.
Target:
EGF R
References
1. Wells, A. et al. (1999) Int. J. Biochem. Cell Biol. 31:637
2. Oda, K. et al. (2005) Mol. Syst. Biol. 1:2005
3. Walker, F. et al. (2009) Human Pathology 40:1517
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