Recombinant Mouse TWEAK
| Code | Size | Price |
|---|
| LEI-T524-25ug | 25 ug | £614.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Mouse
Regulatory Status: RUO
Shipping:
Ambient
Storage:
This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions.
Further Information
Format:
This recombinant protein was 0.2 um filtered and lyophilized from modified Dulbecco?s phosphate buffered saline (1X PBS) pH 7.2 ? 7.3 with no calcium, magnesium, or preservatives.
Formulation:
This recombinant protein was 0.2 um filtered and lyophilized from modified Dulbecco?s phosphate buffered saline (1X PBS) pH 7.2 ? 7.3 with no calcium, magnesium, or preservatives.
Long Description:
TNF-related weak inducer of apoptosis (TWEAK), also known as TNFSF12, is a member of the TNF superfamily. This cytokine has overlapping signaling functions with TNF but displays a much wider tissue distribution. TWEAK is expressed in a variety of tissues, including the adult heart, pancreas, skeletal muscle, small intestine, spleen and peripheral blood lymphocytes. (1). It has pleiotropic biological functions including proapoptotic, proangiogenic and proinflammatory activities (2-3). TWEAK also induces skeletal muscle atrophy (4). It can function as both as a type II transmembrane protein and as a cleaved soluble protein. TWEAK is the ligand for the FN14/TWEAKR receptor.
NCBI Gene:
21944
Purity:
>90% by SDS-PAGE and analyzed by silver stain.
Target:
TWEAK
References
1. Aaron, JW. et al. (2006) Molecular Endo. 20:2528
2. Burkly, LC. et al. (2005) Oncogene 24:2613
3. Young, S. et al. (2003) Biochem. Biophys. Res. Commun. 305:789
4. Kumar, A. et al. (2007) FASEB J. 21:1857
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