Recombinant Human Galectin-8

Product Code: LEI-G704

Code	Size	Price

LEI-G704-50ug

50 ug

£614.00

Quantity:

Prices exclude any Taxes / VAT

Overview

Host Type: Human

Regulatory Status: RUO

Shipping:

Ambient

Storage:

This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions.

Further Information

Format:

This recombinant protein was 0.2 um filtered and lyophilized from modified Dulbecco?s phosphate buffered saline (1X PBS)and Betamercaptoethanol pH 7.2 ? 7.3 with no calcium, magnesium, or preservatives.

Formulation:

Long Description:

Galectin-8, also known Gal-8 and PCTA-1, is a member of the Galectin family which selectively binds β-galactoside residues. The galectins have been implicated in many essential functions including development, differentiation, cell-cell adhesion, cell-matrix interaction, growth regulation, apoptosis and RNA splicing. Galectins lack a typical signal peptide and can be localized to the cytosolic compartments where they have intracellular functions, however, via unknown, non-classical pathways, they can be secreted extracellularly. Gal-8 is expressed in liver, kidney, cardiac muscle, lung and brain. It is also widely expressed in tumoral tissues, such as lung and prostate carcinomas (1). It binds to a subset of cell surface integrins to modulate ECM-integrin interactions (2). As a soluble ligand, Gal-8 can inhibit cell adhesion, however, immoblized Gal-8 has been shown to promote cell adhesion (3). Alternatively spliced transcript variants encoding different isoforms have been identified (4).

NCBI Gene:

3964

Purity:

>97% by SDS-PAGE and analyzed by silver stain.

Target:

Galectin-8

References

1. Nagy, N. et al. (2002) Gut. 50:392 2. C?rcamo, C. et al. (2006) Exp. Cell Res. 312:374 3. Levy, Y. et al. (2001) J. Biol. Chem. 276:31285 4. Bidon, N. et al. (2001) Gene. 274:253