Recombinant Human/Mouse NT-3
| Code | Size | Price |
|---|
| LEI-N219-10ug | 10 ug | £307.00 |
Quantity:
| LEI-N219-100ug | 100 ug | £915.00 |
Quantity:
| LEI-N219-500ug | 500 ug | £4,181.00 |
Quantity:
| LEI-N219-1mg | 1 mg | £6,906.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Human
Regulatory Status: RUO
Shipping:
Ambient
Storage:
The lyophilized protein should be stored desiccated at -20°C. The reconstituted protein can be stored for at least one week at 4°C. For long-term storage of the reconstituted protein aliquot into working volumes and store at -20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.
Further Information
Long Description:
Neurotrophin 3 (NT-3), also known as NGF-2 and HDNF, is a basic protein and member of the NGF family. It is structurally related to β-NGF, BDNF and NT-4 (1), is expressed by neurons of the central nervous systems and can signal through the Trk receptors (2). NT-3 is also expressed in muscles and its expression is down-regulated in denervated muscles. It rapidly potentiates the spontaneous and impulse-evoked synaptic activity of developing neuromuscular synapses in culture and thus appears to be involved in the regulation of functions of developing synapses (3). NT-3 negatively modulates NGF receptor expression and associated nociceptive phenotype in intact neurons, suggesting a beneficial role in treating aspects of neuropathic pain mediated by NGF. In addition, NT-3 is effective at suppressing thermal hyperalgesia associated with chronic constriction injury (CCI) (4). NT-3 affects development of neurons in the embryo when it is expressed in human placenta. Mice born without the ability to make NT-3 show the loss of pro-prioceptive including subsets of mechanoreceptive sensory neurons (5). The amino acid sequences of human, murine and rat NT-3 are identical.
NCBI Gene:
4908
Target:
Neurotrophin-3
References
1. Barde, YA. et al. (1990) Prog. Growth Factor Res. 2:2372. Tessarollo, L. et al. (1993) Development 118:4633. Maisonpierre, PC. et al. (1990) Science 247:14464. Valerie, MK. et al. (2005) J. Neuroscie. 25:7585. Tessarollo, L. et al. (1994) Proc. Natl. Acad. Sci. (USA) 91:11844