Recombinant Human FGF-8e
| Code | Size | Price |
|---|
| LEI-F1113-50ug | 50 ug | £580.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Human
Regulatory Status: RUO
Shipping:
Ambient
Storage:
This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions.
Further Information
Format:
This recombinant protein was lyophilized from a 0.2 um filtered solution in MOPS, EDTA, Dithiothreitol (DTT), and sodium sulphate (Na2SO4).
Formulation:
This recombinant protein was lyophilized from a 0.2 um filtered solution in MOPS, EDTA, Dithiothreitol (DTT), and sodium sulphate (Na2SO4).
Long Description:
Fibroblast growth factor-8 (FGF-8), also known as AIGF and HBGF, is a heparin binding growth factor belonging to the FGF family (1). Proteins of this family play a central role during prenatal development and postnatal growth and regeneration of a variety of tissues, by promoting cellular proliferation and differentiation (2). Alternate splicing of FGF-8 mRNA creates eight secreted isoforms (a-h) in mice and four (a, b, e and f) in humans (3). FGF-8a expands the midbrain in transgenic mice, while FGF-8b transforms the midbrain into cerebellum. FGF-8 activates the ?c? splice forms of receptors FGF R2, FGF R3 and FGF R4, with differential activity among the FGF-8 isoforms. Overexpression of FGF-8 has been shown to increase tumor growth and angiogenesis. FGF-8b shows the strongest receptor affinity and oncogenic transforming capacity, although isoforms a and e have been found in human tumors (4). The adult expression of FGF-8 is restricted to testes and ovaries.
NCBI Gene:
2253
Purity:
>95% by SDS-PAGE and analyzed by silver stain.
Target:
FGF-8e
References
1. Gemel, J. et al. (1996) Genomics 35:2532. Ruess, B. et al. (2003) Cell Tissue Res. 313:1393. Tanaka, S. et al. (2001) Digest. Dis. Sci. 46:10164. Olsen, SK. et al. (2006) Genes Dev. 20:185