Anti-Human CD20 - Purified in vivo GOLD™ Functional Grade
Code | Size | Price |
---|
LEI-C1652-1.0mg | 1.0 mg | £175.00 |
Quantity:
LEI-C1652-5.0mg | 5.0 mg | £380.00 |
Quantity:
LEI-C1652-25mg | 25 mg | £1,014.00 |
Quantity:
LEI-C1652-50mg | 50 mg | £1,556.00 |
Quantity:
LEI-C1652-100mg | 100 mg | £2,159.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Mouse
Antibody Isotype: IgG2b κ
Antibody Clonality: Monoclonal
Antibody Clone: 2H7
Regulatory Status: RUO
Target Species: Human
Applications:
- Flow Cytometry
- In Vivo Assay
- Mass Cytometry (CyTOF)
- Western Blot (WB)
Shipping:
2-8°C
Storage:
Functional grade preclinical antibodies may be stored sterile as received at 2-8°C for up to one month. For longer term storage aseptically aliquot in working volumes without diluting and store at -80°C. Avoid Repeated Freeze Thaw Cycles.
Further Information
Antigen Distribution:
CD20 is present on human pre B lymphocytes and on B lymphocytes, except on plasma cells, and is expressed in tandem with surface IgM. It is also expressed in some follicular dendritic cells and at low levels on a T cell subset.
Concentration:
? 5.0 mg/ml
Conjugate/Tag/Label:
in vivo GOLD™, Purified in vivo Functional Grade
Format:
This monoclonal antibody is aseptically packaged and formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.2 - 7.4 with no carrier protein, potassium, calcium or preservatives added. Due to inherent biochemical properties of antibodies, certain products may be prone to precipitation over time. Precipitation may be removed by aseptic centrifugation and/or filtration.
Formulation:
This monoclonal antibody is aseptically packaged and formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.2 - 7.4 with no carrier protein, potassium, calcium or preservatives added. Due to inherent biochemical properties of antibodies, certain products may be prone to precipitation over time. Precipitation may be removed by aseptic centrifugation and/or filtration.
Immunogen:
Human tonsillar B cells
Long Description:
CD20 is a 33-37 kD transmembrane-spanning phosphoprotein that facilitates optimal B-cell immune response against T-independent antigens. It can exist in a complex with MHC class I, MHC class II, CD53, CD81, and CD82. However, CD20 can also form homo-oligomers. It has been suggested that homo-oligomerization of CD20 forms calcium ion channels in the plasma membrane of B cells. CD20 can be useful in diagnosing B-cell lymphomas and leukemias, and is the target of mAbs in the treatment of all B cell lymphomas, leukemias, and B cell-mediated autoimmune diseases. Interestingly, studies show a link between the immune system's B cells and diabetes mellitus in which anti-CD20 antibodies rendered the T cell antibodies dysfunctional and, hence, unable to cause insulin desensitivity by a B cell antibody-modulated autoimmune response.
NCBI Gene:
931
Purity:
?95% monomer by analytical SEC, >95% by SDS Page
Target:
CD20
References
1. Stashenko, P. et al. (1980) J. Immunol. 125:1678
2. Fang, D. et al. (2005) Cancer Res. 65:9328
3. Bubien, J. K. et al. (1993) J. Cell Biol. 121:1121
4. White, M. W. et al. (1991) J. Immunol. 146:846
5. Cragg, M. S. et al. (2005) Curr. Dir. Autoimmun. 8:140
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