Anti-Mouse CD120b (TNFR2) (Clone TR75-54.7) - DyLight® 488
Code | Size | Price |
---|
LEI-T627-50ug | 50 ug | £159.00 |
Quantity:
LEI-T627-100ug | 100 ug | £211.00 |
Quantity:
LEI-T627-200ug | 200 ug | £291.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Hamster
Antibody Isotype: IgG
Antibody Clonality: Monoclonal
Antibody Clone: TR75-54.7
Regulatory Status: RUO
Target Species: Mouse
Application: Flow Cytometry
Shipping:
2-8°C
Storage:
This DyLight® 488 conjugate is stable when stored at 2-8°C. Do not freeze.
Further Information
Concentration:
0.2 mg/ml
Conjugate/Tag/Label:
DyLight® 488
Format:
This DyLight® 488 conjugate is formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.4, 1% BSA and 0.09% sodium azide as a preservative.
Formulation:
This DyLight® 488 conjugate is formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.4, 1% BSA and 0.09% sodium azide as a preservative.
Immunogen:
E. coli -expressed mouse Type II TNFR
Long Description:
Tumor necrosis factor receptor II (TNF-RII) or CD120b is a 75kD type I transmembrane protein present on most cell types at low levels1 including endothelial cells, cardiac myocytes and prostate cells2; the expression is upregulated upon activation. This receptor binds both TNF-α & TNF-β (aka. LT-α). In association with TRAF1 and TRAF2, the receptor crosslinking induced by TNF-α or LT-α trimers is critical for signal transduction, leading to apoptosis, NF-kB activation, increased expression of proinflammatory genes, tumor necrosis, and cell differentiation depending on cell type and differentiation state. The TR75-54.7 antibody has been shown to block ligand-induced receptor signaling.
NCBI Gene:
21938
Target:
TNFR2
References
1. Zuckerman, KS. et al. (1998) Cancer Res. 58: 22172. Chan, FKM. et al. (2000) Science 288:2351 3. Loetscher, H. et al. (1990) Cell 61:351 4. Rothe, J. et al. (1993) Nature 364:798
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