Anti-Mouse CD54 (ICAM-1) (Clone YN1/1.7.4) - Purified
Code | Size | Price |
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LEI-C2151-100ug | 100 ug | £130.00 |
Quantity:
LEI-C2151-500ug | 500 ug | £232.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rat
Antibody Isotype: IgG2b κ
Antibody Clonality: Monoclonal
Antibody Clone: YN1/1.7.4
Regulatory Status: RUO
Target Species: Mouse
Applications:
- Flow Cytometry
- Immunohistochemistry- Frozen Section (IHC-F)
- Immunoprecipitation (IP)
- Spatial Biology
- Western Blot (WB)
Shipping:
2-8°C
Storage:
This purified antibody is stable when stored at 2-8°C. Do not freeze.
Images
Further Information
Antigen Distribution:
CD54 is present on endothelial cells, lymphocytes, epithelial cells, dendritic cells and keratinocytes.
Concentration:
0.5 mg/ml
Conjugate/Tag/Label:
Purified
Format:
This purified antibody is formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.4, 1% BSA and 0.09% sodium azide as a preservative.
Formulation:
This purified antibody is formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.4, 1% BSA and 0.09% sodium azide as a preservative.
Long Description:
ICAM-1 is a 55 kDa glycoprotein that is part of the Ig superfamily. It is heavily glycosylated to form 75 kDa to 115 kDa. ICAM-1 is known to be an adhesion and viral entry molecule, and its long suspected involevement in signal transduction is being elucidated. The signal-transducing functions of ICAM-1 appear to be mainly associated with proinflammatory pathways. Furthermore, ICAM-1 signaling appears to act as a beacon for inflammatory immune cells such as macrophages and granulocytes bringing about inflammation via lymphocyte trafficking. ICAM-1 is essential for the transmigration of leukocytes out of blood vessels and into tissues, and is a marker of endothelial dysfunction leading to damaging vascular disorders in umbilical and placental vascular tissue of gestational pregnancies. ICAM-1 is the receptor for rhinoviruses (the cause of most common colds) and malaria, and plays an inflammatory role in ocular allergies.
NCBI Gene:
15894
Target:
CD54
References
1. Li, S. et al. (2009) Biochem. Biophys. Res. Commun. 381: 459
2. Wolf, S. et al. (2009) Pharmacol. Rep. 61: 22
3. Ozcan, U. et al. (2009) Arch Gynecol. Obstet.