Anti-Mouse IL-4 (Clone 11B11) - Purified in vivo GOLD™ Functional Grade
| Code | Size | Price |
|---|
| LEI-I-1071-1mg | 1 mg | £175.00 |
Quantity:
| LEI-I-1071-5mg | 5 mg | £380.00 |
Quantity:
| LEI-I-1071-25mg | 25 mg | £1,014.00 |
Quantity:
| LEI-I-1071-50mg | 50 mg | £1,556.00 |
Quantity:
| LEI-I-1071-100mg | 100 mg | £2,159.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rat
Antibody Isotype: IgG1 κ
Antibody Clonality: Monoclonal
Antibody Clone: 11B11
Regulatory Status: RUO
Target Species: Mouse
Applications:
- ELISpot
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Functional Study
- Immunocytochemistry (ICC)
- Immunohistochemistry (IHC)
- Immunoprecipitation (IP)
- In Vivo Assay
- Mass Cytometry (CyTOF)
- Neutralisation
Shipping:
2-8°C
Storage:
Functional grade preclinical antibodies may be stored sterile as received at 2-8°C for up to one month. For longer term storage aseptically aliquot in working volumes without diluting and store at -80°C. Avoid Repeated Freeze Thaw Cycles.
Further Information
Antigen Distribution:
IL-4 is secreted by Th2 cells, NKT cells, mast cells, eosinophils, and basophils.
Concentration:
? 5.0 mg/ml
Conjugate/Tag/Label:
in vivo GOLD™, Purified in vivo Functional Grade
Format:
This monoclonal antibody is aseptically packaged and formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.2 - 7.4 with no carrier protein, potassium, calcium or preservatives added. Due to inherent biochemical properties of antibodies, certain products may be prone to precipitation over time. Precipitation may be removed by aseptic centrifugation and/or filtration.
Formulation:
This monoclonal antibody is aseptically packaged and formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.2 - 7.4 with no carrier protein, potassium, calcium or preservatives added. Due to inherent biochemical properties of antibodies, certain products may be prone to precipitation over time. Precipitation may be removed by aseptic centrifugation and/or filtration.
Immunogen:
Partially Purified Native Mouse IL-4
Long Description:
IL-4 antibody, 11B11, recognizes mouse IL-4, also known as B-cell differentiation factor (BCDF) and B-cell stimulatory factor (BSF1). IL-4 is a pleiotropic 20 kDa cytokine secreted by T helper 2 cells (Th2) cells, natural killer T (NKT) cells, mast cells, eosinophils, and basophils1,2. IL-4 signaling through the IL-4 receptor alpha chain (IL-4Ra) induces the differentiation of naive T cells to Th2 cells3,4 and stimulates B cell differentiation, proliferation, and class switching to IgG1 and IgE isotypes5. In addition, IL-4 is implicated in normal wound healing6,7 and airway inflammation in patients with asthma8.
NCBI Gene:
16189
Purity:
?95% monomer by analytical SEC, >95% by SDS Page
Target:
IL-4
References
1. Yoshimoto T & Paul WE. (1994) J Exp Med. 179(4):1285?95
2. Kipnis J., at al. (2012) J Immunol. 189(9):4213-4219
3. Groth B., et al. (1992) J Exp Med. 176:1091?8
4. Murphy KM., et al. (1992) Proc Natl Acad Sci USA. 89:6065?9
5. Paul WE., et al. (1999) Annual Rev Immunol. 17:701-38
6. Maquart FX., et al. (2000) Lab Invest. 80(8):1337-43
7. Godeau, G., et al. (2000) Lab Invest. 80,1337?1343
8. Steinke JW & Borish L. (2001) Respir Res. 2(2):66-70
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