Anti-Mouse IL-4 (Clone 11B11) - APC
| Code | Size | Price |
|---|
| LEI-I-1074-50ug | 50 ug | £209.00 |
Quantity:
| LEI-I-1074-100ug | 100 ug | £280.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rat
Antibody Isotype: IgG1 κ
Antibody Clonality: Monoclonal
Antibody Clone: 11B11
Regulatory Status: RUO
Target Species: Mouse
Application: Flow Cytometry
Shipping:
2-8°C
Storage:
This Allophyc°Cyanin (APC) conjugate is stable when stored at 2-8°C. Do not freeze.
Further Information
Antigen Distribution:
IL-4 is secreted by Th2 cells, NKT cells, mast cells, eosinophils, and basophils.
Concentration:
0.2 mg/ml
Conjugate/Tag/Label:
Allophycocyanin (APC)
Format:
This Allophycocyanin (APC) conjugate is formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.4, 1% BSA and 0.09% sodium azide as a preservative.
Formulation:
This Allophycocyanin (APC) conjugate is formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.4, 1% BSA and 0.09% sodium azide as a preservative.
Immunogen:
Partially Purified Native Mouse IL-4
Long Description:
IL-4 antibody, 11B11, recognizes mouse IL-4, also known as B-cell differentiation factor (BCDF) and B-cell stimulatory factor (BSF1). IL-4 is a pleiotropic 20 kDa cytokine secreted by T helper 2 cells (Th2) cells, natural killer T (NKT) cells, mast cells, eosinophils, and basophils1,2. IL-4 signaling through the IL-4 receptor alpha chain (IL-4Ra) induces the differentiation of naive T cells to Th2 cells3,4 and stimulates B cell differentiation, proliferation, and class switching to IgG1 and IgE isotypes5. In addition, IL-4 is implicated in normal wound healing6,7 and airway inflammation in patients with asthma8.
NCBI Gene:
16189
Target:
IL-4
References
1. Yoshimoto T & Paul WE. (1994) J Exp Med. 179(4):1285?95
2. Kipnis J., at al. (2012) J Immunol. 189(9):4213-4219
3. Groth B., et al. (1992) J Exp Med. 176:1091?8
4. Murphy KM., et al. (1992) Proc Natl Acad Sci USA. 89:6065?9
5. Paul WE., et al. (1999) Annual Rev Immunol. 17:701-38
6. Maquart FX., et al. (2000) Lab Invest. 80(8):1337-43
7. Godeau, G., et al. (2000) Lab Invest. 80,1337?1343
8. Steinke JW & Borish L. (2001) Respir Res. 2(2):66-70
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