Anti-Mouse CD278 (ICOS) - Purified in vivo GOLD™ Functional Grade
| Code | Size | Price |
|---|
| LEI-C2258-1.0mg | 1.0 mg | £175.00 |
Quantity:
| LEI-C2258-5.0mg | 5.0 mg | £380.00 |
Quantity:
| LEI-C2258-25mg | 25 mg | £1,014.00 |
Quantity:
| LEI-C2258-50mg | 50 mg | £1,556.00 |
Quantity:
| LEI-C2258-100mg | 100 mg | £2,159.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rat
Antibody Isotype: IgG2b κ
Antibody Clonality: Monoclonal
Antibody Clone: 7E.17G9
Regulatory Status: RUO
Target Species: Mouse
Applications:
- Blocking
- Functional Study
- In Vivo Assay
- Western Blot (WB)
Shipping:
2-8°C
Storage:
Functional grade preclinical antibodies may be stored sterile as received at 2-8°C for up to one month. For longer term storage aseptically aliquot in working volumes without diluting and store at -80°C. Avoid Repeated Freeze Thaw Cycles.
Further Information
Antigen Distribution:
ICOS is expressed on activated T cells and APCs including splenic B cells, dendritic cells, and macrophages.
Concentration:
? 5.0 mg/ml
Conjugate/Tag/Label:
in vivo GOLD™, Purified in vivo Functional Grade
Format:
This monoclonal antibody is aseptically packaged and formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.2 - 7.4 with no carrier protein, potassium, calcium or preservatives added. Due to inherent biochemical properties of antibodies, certain products may be prone to precipitation over time. Precipitation may be removed by aseptic centrifugation and/or filtration.
Formulation:
This monoclonal antibody is aseptically packaged and formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.2 - 7.4 with no carrier protein, potassium, calcium or preservatives added. Due to inherent biochemical properties of antibodies, certain products may be prone to precipitation over time. Precipitation may be removed by aseptic centrifugation and/or filtration.
Immunogen:
Mouse ICOS cDNA and ICOS hexahistidine fusion protein
Long Description:
CD278 (ICOS) belongs to the CD28 and CTLA-4 cell-surface receptor family. It forms homodimers (47-57kD) and enhances all basic T cell responses to a foreign antigen, specifically proliferation, secretion of lymphokines, up-regulation of molecules that mediate cell-cell interaction, and effective help for antibody secretion by B cells. ICOS signaling is also an important regulator for T cell homeostasis. ICOS plays a role in humoral immune response and is thought to have involvement in the development of Th2 cells and to play a protective role in inflammatory autoimmune diseases.
NCBI Gene:
54167
Purity:
?95% monomer by analytical SEC, >95% by SDS Page
Target:
CD278
References
1. Flavell, R. A. et al. (2001) Nature 409:97
2. Bachmann, M. F. et al. (2000) J. Exp. Med. 192:53
3. Kroczek, R. A. et al. (1999) Nature 397:263
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