Anti-Mouse CD278 (ICOS) - Biotin
| Code | Size | Price |
|---|
| LEI-C2259-50ug | 50 ug | £201.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rat
Antibody Isotype: IgG2b
Antibody Clonality: Monoclonal
Antibody Clone: 7E.17G9
Regulatory Status: RUO
Target Species: Mouse
Application: Flow Cytometry
Shipping:
2-8°C
Storage:
This biotinylated antibody is stable when stored at 2-8°C. Do not freeze.
Further Information
Antigen Distribution:
ICOS is expressed on activated T cells and APCs including splenic B cells, dendritic cells, and macrophages.
Concentration:
0.5 mg/ml
Conjugate/Tag/Label:
Biotin
Format:
This biotinylated antibody is formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.4, 1% BSA and 0.09% sodium azide as a preservative.
Formulation:
This biotinylated antibody is formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.4, 1% BSA and 0.09% sodium azide as a preservative.
Immunogen:
Purified Recombinant Mouse ICOS
Long Description:
CD278 (ICOS) belongs to the CD28 and CTLA-4 cell-surface receptor family. It forms homodimers (47-57kD) and enhances all basic T cell responses to a foreign antigen, specifically proliferation, secretion of lymphokines, up-regulation of molecules that mediate cell-cell interaction, and effective help for antibody secretion by B cells. ICOS signaling is also an important regulator for T cell homeostasis. ICOS plays a role in humoral immune response and is thought to have involvement in the development of Th2 cells and to play a protective role in inflammatory autoimmune diseases.
NCBI Gene:
54167
Target:
CD278
References
1. Flavell, R. A. et al. (2001) Nature 409:97
2. Bachmann, M. F. et al. (2000) J. Exp. Med. 192:53
3. Kroczek, R. A. et al. (1999) Nature 397:263