Anti-Human IL-4 - Purified in vivo GOLD™ Functional Grade

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Leinco Technologies
Product Code: LEI-I-1163
Product Group: Primary Antibodies
CodeSizePrice
LEI-I-1163-1.0mg1 mg£290.00
Quantity:
LEI-I-1163-5mg5 mg£716.00
Quantity:
LEI-I-1163-25mg25 mg£1,740.00
Quantity:
LEI-I-1163-50mg50 mg£2,878.00
Quantity:
LEI-I-1163-100mg100 mg£4,102.00
Quantity:
Prices exclude any Taxes / VAT

Overview

Host Type: Rat
Antibody Isotype: IgG1 κ
Antibody Clonality: Monoclonal
Antibody Clone: MP4-25D2
Regulatory Status: RUO
Target Species: Human
Applications:
  • Immunohistochemistry (IHC)
  • In Vivo Assay
  • Mass Cytometry (CyTOF)
  • Neutralisation
  • Western Blot (WB)
Shipping:
2-8°C
Storage:
Functional grade preclinical antibodies may be stored sterile as received at 2-8°C for up to one month. For longer term storage aseptically aliquot in working volumes without diluting and store at -80°C. Avoid Repeated Freeze Thaw Cycles.

Further Information

Concentration:
? 2.0 mg/ml
Conjugate/Tag/Label:
in vivo GOLD™, Purified in vivo Functional Grade
Format:
This monoclonal antibody is aseptically packaged and formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.2 - 7.4 with no carrier protein, potassium, calcium or preservatives added. Due to inherent biochemical properties of antibodies, certain products may be prone to precipitation over time. Precipitation may be removed by aseptic centrifugation and/or filtration.
Formulation:
This monoclonal antibody is aseptically packaged and formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.2 - 7.4 with no carrier protein, potassium, calcium or preservatives added. Due to inherent biochemical properties of antibodies, certain products may be prone to precipitation over time. Precipitation may be removed by aseptic centrifugation and/or filtration.
Immunogen:
CHO-expressed, recombinant human IL-4
Long Description:
IL-4 is a 15-19 kD pleiotropic immune cytokine secreted by activated TH2 cells. It has many biological roles, including the regulation in humoral and adaptive immunity, the inhibition of bone resorption, the stimulation of activated B-cell and T-cell proliferation, and initiation of allergic responses. Moreover, IL-4 induces a positive feedback loop by stimulating differentiation of naive helper T cells, or Th0 cells, to Th2 cells which in turn secrete more IL-4. Increased IL-4 production and overproduction of IL-4R are found in many cancers. IL-4 has a significant effect on tumor progression by increasing apoptosis resistance via tumor growth enhancement. IL-4 may also play a part in the immune dysregulation that occurs in most HIV-1 infected patients.
NCBI Gene:
3565
Purity:
?95% monomer by analytical SEC, >95% by SDS Page
Target:
IL-4

References

1. Pike, JW. et al. (2001) PNAS 98: 24432. Finkelman, FD. et al. (2003) J Immunol. 170: 38353. Kaplan, MH. et al. (2008) J Immunol. 180: 3551