Anti-Mouse PD-L2 (B7-DC) - Purified in vivo GOLD™ Functional Grade
| Code | Size | Price |
|---|
| LEI-C2292-1.0mg | 1.0 mg | £175.00 |
Quantity:
| LEI-C2292-5.0mg | 5.0 mg | £380.00 |
Quantity:
| LEI-C2292-25mg | 25 mg | £1,014.00 |
Quantity:
| LEI-C2292-50mg | 50 mg | £1,556.00 |
Quantity:
| LEI-C2292-100mg | 100 mg | £2,159.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rat
Antibody Isotype: IgG2a κ
Antibody Clonality: Monoclonal
Antibody Clone: TY25
Regulatory Status: RUO
Target Species: Mouse
Applications:
- Flow Cytometry
- Immunohistochemistry- Frozen Section (IHC-F)
- Immunoprecipitation (IP)
- In Vivo Assay
- Western Blot (WB)
Shipping:
2-8°C
Storage:
Functional grade preclinical antibodies may be stored sterile as received at 2-8°C for up to one month. For longer term storage aseptically aliquot in working volumes without diluting and store at -80°C. Avoid Repeated Freeze Thaw Cycles.
Further Information
Antigen Distribution:
PD-L2 is expressed on macrophages and a subset of dendritic cells (DCs).
Concentration:
? 5.0 mg/ml
Conjugate/Tag/Label:
in vivo GOLD™, Purified in vivo Functional Grade
Format:
This monoclonal antibody is aseptically packaged and formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.2 - 7.4 with no carrier protein, potassium, calcium or preservatives added. Due to inherent biochemical properties of antibodies, certain products may be prone to precipitation over time. Precipitation may be removed by aseptic centrifugation and/or filtration.
Formulation:
This monoclonal antibody is aseptically packaged and formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.2 - 7.4 with no carrier protein, potassium, calcium or preservatives added. Due to inherent biochemical properties of antibodies, certain products may be prone to precipitation over time. Precipitation may be removed by aseptic centrifugation and/or filtration.
Immunogen:
Purified transfected mouse B7-DC cell line
Long Description:
PD-L2 antibody, clone TY25, recognizes mouse programmed death ligand 2 (PDL-2), also known as B7-DC and CD273. PD-L2 is a 42 kDa type I transmembrane glycoprotein that belongs to the B7 family of the immunoglobulin (Ig) receptor superfamily. PD-L2 is an inhibitory ligand primarily expressed on antigen-presenting cells, including macrophages and a subset of dendritic cells (DCs). Its receptor, PD-1, is expressed by CD4-CD8- thymocytes as well as CD4 and CD8 T cells, monocytes, DCs, and B cells upon activation1. Binding of PD-L2 to PD-1 on CD4 and CD8 T cells inhibits T cell receptor (TCR) signaling, negatively regulating T cell proliferation, cytokine production, and cytotoxic activity2. PD-L2 is expressed on many tumor types3,4 and is associated with unfavorable prognosis in patients with solid tumors5.
NCBI Gene:
58205
Purity:
?95% monomer by analytical SEC, >95% by SDS Page
Target:
PD-L2
References
1.) Francisco LM, et al. (2010) Immunol Rev. 236:219-242
2.) Latchman Y, et al. (2001) Nat Immunol. 2(3):261-8
3.) Ahmad SM, et al. (2018) Oncoimmunology. 7:e1390641
4.) Panjwani PK, et al. (2018) Hum Pathol. 71:91?9
5.) Yang H, et al. (2019) Front Oncol. 9:47
6.) Gubin, M. et al. (2018) Cell. 175(4):1014?1030.e19 Journal Link
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