Leinco Technologies

Anti-Mouse CD137 (4-1BB) - Purified in vivo PLATINUM™ Functional Grade

Product Code:
 
LEI-C2835
Product Group:
 
Primary Antibodies
Host Type:
 
Rat
Antibody Isotype:
 
IgG2a
Antibody Clonality:
 
Monoclonal
Antibody Clone:
 
3H3
Regulatory Status:
 
RUO
Target Species:
 
Mouse
Applications:
  • Enzyme-Linked Immunosorbent Assay (ELISA)
  • Functional Study
  • In Vivo Assay
  • Western Blot (WB)
Shipping:
 
2-8°C
Storage:
 
Functional grade preclinical antibodies may be stored sterile as received at 2-8°C for up to one month. For longer term storage aseptically aliquot in working volumes without diluting and store at -80°C. Avoid Repeated Freeze Thaw Cycles.
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CodeSizePrice
LEI-C2835-1.0mg1.0 mg£283.00
Quantity:
LEI-C2835-5.0mg5.0 mg£456.00
Quantity:
LEI-C2835-25mg25 mg£1,335.00
Quantity:
LEI-C2835-50mg50 mg£1,938.00
Quantity:
LEI-C2835-100mg100 mg£2,741.00
Quantity:
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This product comes from: US.
Typical lead time: 14-21 working days.
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Further Information

Antigen Distribution:
4-1BB is expressed on activated B cells and T cells, macrophages, and dendritic cells.
Concentration:
? 5.0 mg/ml
Conjugate/Tag/Label:
Purified in vivo Functional Grade, in vivo PLATINUM™
Format:
This monoclonal antibody is aseptically packaged and formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.2 - 7.4 with no carrier protein, potassium, calcium or preservatives added. Due to inherent biochemical properties of antibodies, certain products may be prone to precipitation over time. Precipitation may be removed by aseptic centrifugation and/or filtration.
Formulation:
This monoclonal antibody is aseptically packaged and formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.2 - 7.4 with no carrier protein, potassium, calcium or preservatives added. Due to inherent biochemical properties of antibodies, certain products may be prone to precipitation over time. Precipitation may be removed by aseptic centrifugation and/or filtration.
Immunogen:
Recombinant Mouse CD137 human Fc fusion protein
Long Description:
4-1BB (CD137) is a 39 kD transmembrane protein that is a member of the tumor necrosis factor (TNF) receptor family and is a co-stimulatory molecule that plays a role in T-cell-mediated proliferative response. When binding its ligand, CD137 provides costimulatory signals to both CD4 and CD8 T cells via the activation of NF-?B, c-Jun and p38 downstream pathways. Crosslinking of CD137 boosts T cell proliferation, IL-2 secretion, survival and cytolytic activity. Furthermore, it can increase immune activity to eliminate tumors in mice. Agonistic anti-CD137 antibodies have been reported to stimulate a more intense immune system attack on cancers.
NCBI Gene:
21942
Purity:
?98% monomer by analytical SEC, >95% by SDS Page
Target:
4-1BB