Leinco Technologies

Anti-Mouse CD4 (Clone GK1.5) - Purified in vivo PLATINUM™ Functional Grade

Product Code:
 
LEI-C2838
Product Group:
 
Primary Antibodies
Host Type:
 
Rat
Antibody Isotype:
 
IgG2b κ
Antibody Clonality:
 
Monoclonal
Antibody Clone:
 
GK1.5
Regulatory Status:
 
RUO
Target Species:
 
Mouse
Applications:
  • Blocking
  • Co-stimulation
  • Depletion
  • Flow Cytometry
  • Functional Study
  • Immunohistochemistry (IHC)
  • Immunoprecipitation (IP)
  • In Vivo Assay
  • Mass Cytometry (CyTOF)
Shipping:
 
2-8°C
Storage:
 
Functional grade preclinical antibodies may be stored sterile as received at 2-8°C for up to one month. For longer term storage aseptically aliquot in working volumes without diluting and store at -80°C. Avoid Repeated Freeze Thaw Cycles.
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CodeSizePrice
LEI-C2838-1.0mg1.0 mg£283.00
Quantity:
LEI-C2838-5mg5 mg£456.00
Quantity:
LEI-C2838-25mg25 mg£1,335.00
Quantity:
LEI-C2838-50mg50 mg£1,938.00
Quantity:
LEI-C2838-100mg100 mg£2,741.00
Quantity:
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This product comes from: US.
Typical lead time: 14-21 working days.
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  • Further Information
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Further Information

Antigen Distribution:
The CD4/L3T4 antigen is expressed by the helper/inducer subset of mouse T-cells. The antigen is present on approximately 80% of thymocytes, 20% of spleen cells and 60% of lymph node cells. The expression of L3T4 correlates with class II MHC antigen reactivity on cloned T-cell lines.
Concentration:
? 5.0 mg/ml
Conjugate/Tag/Label:
Purified in vivo Functional Grade, in vivo PLATINUM™
Format:
This monoclonal antibody is aseptically packaged and formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.2 - 7.4 with no carrier protein, potassium, calcium or preservatives added. Due to inherent biochemical properties of antibodies, certain products may be prone to precipitation over time. Precipitation may be removed by aseptic centrifugation and/or filtration.
Formulation:
This monoclonal antibody is aseptically packaged and formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.2 - 7.4 with no carrier protein, potassium, calcium or preservatives added. Due to inherent biochemical properties of antibodies, certain products may be prone to precipitation over time. Precipitation may be removed by aseptic centrifugation and/or filtration.
Immunogen:
Mouse CTL clone V4
Long Description:
CD4 (cluster of differentiation 4) is a glycoprotein expressed on the surface of T helper cells, regulatory T cells, monocytes, macrophages, and dendritic cells. CD4 interacts with class II molecules of the major histocompatibility complex (MHC) enhancing the signal for T-cell activation.6
NCBI Gene:
12504
Purity:
?98% monomer by analytical SEC, >95% by SDS Page
Target:
CD4

References

1.) Ardolino, M. et al. (2018) J Clin Invest. 128(10):4654-4668. PubMed 2.) Schreiber, RD. et al. (2017) Cancer Immunol Res. 5(2):106-117. PubMed 3.) Nicolas, JF. et al. (2002) J Immunol.168(6):3079-87. Article Link 4.) Shin, H. et al. (2018) J Virol. 92(7): e00038-18. PubMed 5.) Chiang, BL. et al. (2001) Immunology. 2001 103(3): 301?309. PubMed 6.) Hendrickson, WA. et al. (1994) Structure 2: 59 7.) Skyberg, J. A. et al. (2020) Infection and Immunity. 88: 5 Journal Link 8.) Hawman DW, et al. (2021) Microorganisms 9(2):279 Journal Link