Leinco Technologies

Anti-Mouse NK1.1 - Purified in vivo PLATINUM™ Functional Grade

Product Code:
 
LEI-N268
Product Group:
 
Primary Antibodies
Host Type:
 
Mouse
Antibody Isotype:
 
IgG2a κ
Antibody Clonality:
 
Monoclonal
Antibody Clone:
 
PK136
Regulatory Status:
 
RUO
Target Species:
 
Mouse
Applications:
  • Blocking
  • Depletion
  • Flow Cytometry
  • Immunoprecipitation (IP)
  • In Vivo Assay
  • Mass Cytometry (CyTOF)
  • Western Blot (WB)
Shipping:
 
2-8°C
Storage:
 
Functional grade preclinical antibodies may be stored sterile as received at 2-8°C for up to one month. For longer term storage aseptically aliquot in working volumes without diluting and store at -80°C. Avoid Repeated Freeze Thaw Cycles.
 

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CodeSizePrice
LEI-N268-1.0mg1.0 mg£283.00
Quantity:
LEI-N268-5.0mg5.0 mg£456.00
Quantity:
LEI-N268-25mg25 mg£1,335.00
Quantity:
LEI-N268-50mg50 mg£1,938.00
Quantity:
LEI-N268-100mg100 mg£2,741.00
Quantity:
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This product comes from: US.
Typical lead time: 14-21 working days.
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Further Information

Antigen Distribution:
NK-1.1 is encoded by the NKR-P1B/NKR-P1C gene and expressed on NK cells and NK-T cells in some mouse strains, including C57BL/6, FVB/N, and NZB, but not AKR, BALB/c, CBA/J, C3H, DBA/1, DBA/2, NOD, SJL, and 129.
Concentration:
? 5.0 mg/ml
Conjugate/Tag/Label:
Purified in vivo Functional Grade, in vivo PLATINUM™
Format:
This monoclonal antibody is aseptically packaged and formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.2 - 7.4 with no carrier protein, potassium, calcium or preservatives added. Due to inherent biochemical properties of antibodies, certain products may be prone to precipitation over time. Precipitation may be removed by aseptic centrifugation and/or filtration.
Formulation:
This monoclonal antibody is aseptically packaged and formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.2 - 7.4 with no carrier protein, potassium, calcium or preservatives added. Due to inherent biochemical properties of antibodies, certain products may be prone to precipitation over time. Precipitation may be removed by aseptic centrifugation and/or filtration.
Immunogen:
NK-1+ cells from mouse spleen and bone marrow
Long Description:
NK1.1 is a type II membrane protein that is part of the C-type lectin superfamily. NK1.1 contains a transmembrane domain and a cytoplasmic domain that are characteristic of C-type lectins. The function of NK cells is to mediate cytotoxicity and to secrete cytokines after immune stimulation. NK1.1 has been correlated with lysis of tumor cells In vitro and rejection of bone marrow allografts In vivo. It is also involved in NK cell activation, IFN-γ production, and cytotoxic granule release. NK-1.1 is commonly used as a mouse NK cell marker.
NCBI Gene:
17059
Purity:
?98% monomer by analytical SEC, >95% by SDS Page
Target:
NK1.1

References

1. Ardolino, M. et al. (2018) J Clin Invest. 128(10):4654-4668. PubMed 2. Koo, GC. and Peppard, JR. (1986) Hybridoma 3:301