Anti-Mouse CD86 - Purified in vivo PLATINUM™ Functional Grade
Code | Size | Price |
---|
LEI-C6158-1.0mg | 1.0 mg | £283.00 |
Quantity:
LEI-C6158-5.0mg | 5.0 mg | £456.00 |
Quantity:
LEI-C6158-25mg | 25 mg | £1,335.00 |
Quantity:
LEI-C6158-50mg | 50 mg | £1,938.00 |
Quantity:
LEI-C6158-100mg | 100 mg | £2,741.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rat
Antibody Isotype: IgG2a κ
Antibody Clonality: Monoclonal
Antibody Clone: GL1
Regulatory Status: RUO
Target Species: Mouse
Applications:
- Blocking
- Enzyme-Linked Immunosorbent Assay (ELISA)
- In Vivo Assay
- Western Blot (WB)
Shipping:
2-8°C
Storage:
Functional grade preclinical antibodies may be stored sterile as received at 2-8°C for up to one month. For longer term storage aseptically aliquot in working volumes without diluting and store at -80°C. Avoid Repeated Freeze Thaw Cycles.
Images
Further Information
Antigen Distribution:
CD86 is expressed on activated B and T cells, macrophages, dendritic cells, and astrocytes.
Concentration:
? 5.0 mg/ml
Conjugate/Tag/Label:
Purified in vivo Functional Grade, in vivo PLATINUM™
Format:
This monoclonal antibody is aseptically packaged and formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.2 - 7.4 with no carrier protein, potassium, calcium or preservatives added. Due to inherent biochemical properties of antibodies, certain products may be prone to precipitation over time. Precipitation may be removed by aseptic centrifugation and/or filtration.
Formulation:
This monoclonal antibody is aseptically packaged and formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.2 - 7.4 with no carrier protein, potassium, calcium or preservatives added. Due to inherent biochemical properties of antibodies, certain products may be prone to precipitation over time. Precipitation may be removed by aseptic centrifugation and/or filtration.
Immunogen:
LPS-activated CBA/Ca mouse splenic B cells
Long Description:
CD86 is an 80kD Ig superfamily member that is involved in immunoglobulin class-switching and activation of NK cell-mediated cytotoxicity. CD80 is closely related to, and works in tandem with CD86 to prime T- cells. CD86 is expressed earlier in the immune response than CD80. The ligation of CD28 on T cells with CD80 and CD86 on APCs co-stimulates T cells resulting in enhanced cell activation, proliferation, and cytokine production. CD86 can also bind to CTLA-4 to deliver an inhibitory signal to T cells.
NCBI Gene:
12524
Purity:
?98% monomer by analytical SEC, >95% by SDS Page
Target:
B7-2
References
1. Hathcock, K.S. et al.. (1993) Science 262(5135:905-7
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