Anti-Mouse TNFα - Purified in vivo PLATINUM™ Functional Grade
| Code | Size | Price |
|---|
| LEI-T703-1.0mg | 1.0 mg | £283.00 |
Quantity:
| LEI-T703-5.0mg | 5.0 mg | £456.00 |
Quantity:
| LEI-T703-25mg | 25 mg | £1,335.00 |
Quantity:
| LEI-T703-50mg | 50 mg | £1,938.00 |
Quantity:
| LEI-T703-100mg | 100 mg | £2,741.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Hamster
Antibody Isotype: IgG
Antibody Clonality: Monoclonal
Antibody Clone: TN3-19.12
Regulatory Status: RUO
Target Species: Mouse
Applications:
- Immunoprecipitation (IP)
- In Vivo Assay
- Neutralisation
- Western Blot (WB)
Shipping:
2-8°C
Storage:
Functional grade preclinical antibodies may be stored sterile as received at 2-8°C for up to one month. For longer term storage aseptically aliquot in working volumes without diluting and store at -80°C. Avoid Repeated Freeze Thaw Cycles.
Further Information
Antigen Distribution:
TNF-α is secreted by macrophages, monocytes, neutrophils, T cells, B cells, NK cells, LAK cells.
Concentration:
2.0 mg/ml
Conjugate/Tag/Label:
in vivo PLATINUM™
Format:
This monoclonal antibody is aseptically packaged and formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.2 - 7.4 with no carrier protein, potassium, calcium or preservatives added. Due to inherent biochemical properties of antibodies, certain products may be prone to precipitation over time. Precipitation may be removed by aseptic centrifugation and/or filtration.
Formulation:
This monoclonal antibody is aseptically packaged and formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.2 - 7.4 with no carrier protein, potassium, calcium or preservatives added. Due to inherent biochemical properties of antibodies, certain products may be prone to precipitation over time. Precipitation may be removed by aseptic centrifugation and/or filtration.
Immunogen:
Purified Recombinant Mouse TNF-α
Long Description:
TNF-α is a 17.5 kD protein that mediates inflammation and immunity caused by the invasion of viruses, bacteria, and parasites by initiating a cascade of cytokines that increase vascular permeability, thus bringing macrophages and neutrophils to the site of infection. TNF-α secreted by the macrophage causes the blood to clot which provides containment of the infection. TNF-α binding to surface receptors brings about various biologic activities that include cytolysis and cytostasis of many tumor cell lines In vitro, hemorraghic necrosis of tumors In vivo, increased fibroblast proliferation, and enhanced chemotaxis and phagocytosis in neutrophils.
NCBI Gene:
21296
Purity:
?98% monomer by analytical SEC, >95% by SDS Page
Target:
TNF-α
References
1.) El-Harith el-HA et al. (2004) Saudi Med J. 25: 135
2.) Adolf GR et al. (1990) Infec Immun. 58: 3996
3.) Kanneganti et al. (2020) bioRxiv 361048 Journal Link
4.) Fhogartaigh, C.N. et al. (2020) Nat Commun 11, 6385 Journal Link
5.) Karki et al. (2021) Cell. 184:149?168 Journal Link
6.) Karki, R. et al. (2021) Cell 184(1):149?168.e17 Journal Link
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