Anti-Mouse CD54 (ICAM-1) (Clone YN1/1.7.4) - Purified (PhenoCycler-Fusion (CODEX)® Ready)

Product Code: LEI-C527

Code	Size	Price

LEI-C527-50ug

50 ug

£167.00

Quantity:

Prices exclude any Taxes / VAT

Overview

Host Type: Rat

Antibody Isotype: IgG2b κ

Antibody Clonality: Monoclonal

Antibody Clone: YN1/1.7.4

Regulatory Status: RUO

Target Species: Mouse

Applications:

Immunohistochemistry- Frozen Section (IHC-F)
Spatial Biology

Shipping:

2-8°C

Storage:

This antibody is stable for at least one week when stored at 2-8°C. For long term storage aliquot in working volumes without diluting and store at -20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.

Further Information

Antigen Distribution:

CD54 is present on endothelial cells, lymphocytes, epithelial cells, dendritic cells and keratinocytes.

Concentration:

0.5 mg/ml

Conjugate/Tag/Label:

Purified (PhenoCycler® Ready)

Format:

This purified antibody is formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.4.

Formulation:

This purified antibody is formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.4.

Long Description:

ICAM-1 is a 55 kDa glycoprotein that is part of the Ig superfamily. It is heavily glycosylated to form 75 kDa to 115 kDa. ICAM-1 is known to be an adhesion and viral entry molecule, and its long suspected involevement in signal transduction is being elucidated. The signal-transducing functions of ICAM-1 appear to be mainly associated with proinflammatory pathways. Furthermore, ICAM-1 signaling appears to act as a beacon for inflammatory immune cells such as macrophages and granulocytes bringing about inflammation via lymphocyte trafficking. ICAM-1 is essential for the transmigration of leukocytes out of blood vessels and into tissues, and is a marker of endothelial dysfunction leading to damaging vascular disorders in umbilical and placental vascular tissue of gestational pregnancies. ICAM-1 is the receptor for rhinoviruses (the cause of most common colds) and malaria, and plays an inflammatory role in ocular allergies.

NCBI Gene:

15894

Target:

CD54

References

1. Li, S. et al. (2009) Biochem. Biophys. Res. Commun. 381: 459 2. Wolf, S. et al. (2009) Pharmacol. Rep. 61: 22 3. Ozcan, U. et al. (2009) Arch Gynecol. Obstet.