Anti-Andes Virus (Hantavirus) (Clone: ANDV-44)

Product Code: LEI-LT551

Code	Size	Price

LEI-LT551-250ug

250 ug

£231.00

Quantity:

LEI-LT551-1.0mg

1.0 mg

£410.00

Quantity:

Prices exclude any Taxes / VAT

Overview

Host Type: Virus

Antibody Isotype: Human IgG1

Antibody Clonality: Monoclonal

Antibody Clone: ANDV-44

Regulatory Status: RUO

Target Species:

Andes virus
Hantaan orthohantavirus (HTNV)
Virus

Applications:

Enzyme-Linked Immunosorbent Assay (ELISA)
Neutralisation

Shipping:

Blue Ice

Storage:

Functional grade preclinical antibodies may be stored sterile as received at 2-8°C for up to one year. For longer term storage aseptically aliquot in working volumes without diluting and store at ? -70°C. Avoid Repeated Freeze Thaw Cycles.

Further Information

Concentration:

? 5.0 mg/ml

Conjugate/Tag/Label:

Purified No Carrier Protein

Format:

This recombinant monoclonal antibody is aseptically packaged and formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.2 - 7.4 with no carrier protein, potassium, calcium or preservatives added. Due to inherent biochemical properties of antibodies, certain products may be prone to precipitation over time. Precipitation may be removed by aseptic centrifugation and/or filtration.

Formulation:

Immunogen:

This human monoclonal antibody clone ANDV-44 was generated as part of a panel using a B cell hybridoma method from an individual previously infected with ANDV8.

Long Description:

Hantavirus or Andes Virus is an enveloped, negative-sensed, single-stranded RNA virus in the bunyavirus family1. ?New World? hantaviruses (NWH) are found in the Americas and may cause hantavirus pulmonary syndrome (HPS)2. ?Old World? hantaviruses (OWH) are found mainly in Europe and Asia and may cause hemorrhagic fever with renal syndrome. Each hantavirus serotype has a specific rodent host species, and infection is spread primarily by aerosolized feces, urine, or saliva, with the exception of Andes Virus (ANDV) which is also capable of human-to-human transmission3,4. ANDV, a NWH found in South America5, has a high fatality rate of up to 40%6. Clinical research shows that high titers of neutralizing antibodies in patient serum correlate with increased survival7, and monoclonal antibodies (mAbs), including ANDV-44, isolated from HPS survivors protect Syrian hamsters from ANDV postinfection6-8.

Purity:

?95% monomer by analytical SEC

Target:

Andes virus

References

1. Centers for Disease Control and Prevention, National Center for Emerging and Zoonotic Infectious Diseases (NCEZID), Division of High-Consequence Pathogens and Pathology (DHCPP), Link 2. Centers for Disease Control and Prevention, National Center for Emerging and Zoonotic Infectious Diseases (NCEZID), Division of High-Consequence Pathogens and Pathology (DHCPP), Link 3. Padula PJ, Edelstein A, Miguel SD, et al. Virology. 241:323?330. 1998. 4. Martinez VP, Bellomo C, San Juan J, et al. Emerg Infect Dis. 11:1848?1853. 2005. 5. Centers for Disease Control and Prevention, National Center for Emerging and Zoonotic Infectious Diseases (NCEZID), Division of High-Consequence Pathogens and Pathology (DHCPP), https://www.cdc.gov/hantavirus/resources/andes-virus.html 6. Williamson BN, Prescott J, Garrido JL, et al. Emerg Infect Dis. 27(10):2707-2710. 2021. 7. Bharadwaj M, Nofchissey R, Goade D, et al. J Infect Dis. 182: 43?48. 2000. 8. Engdahl TB, Kuzmina NA, Ronk AJ, et al. Cell Rep. 35(5):109086. 2021. 9. Garrido, JL, et al. (2018) Sci Transl Med.10(468):eaat6420.

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