Anti-Sin Nombre Virus (Hantavirus) (Clone: SNV-53)
| Code | Size | Price |
|---|
| LEI-LT552-250ug | 250 ug | £231.00 |
Quantity:
| LEI-LT552-1.0mg | 1.0 mg | £410.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Virus
Antibody Isotype: Human IgG1
Antibody Clonality: Monoclonal
Antibody Clone: SNV-53
Regulatory Status: RUO
Target Species:
- Hantaan orthohantavirus (HTNV)
- Sin Nombre Virus
- Virus
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Neutralisation
Shipping:
Blue Ice
Storage:
Functional grade preclinical antibodies may be stored sterile as received at 2-8°C for up to one year. For longer term storage aseptically aliquot in working volumes without diluting and store at ? -70°C. Avoid Repeated Freeze Thaw Cycles.
Further Information
Concentration:
? 5.0 mg/ml
Conjugate/Tag/Label:
Purified No Carrier Protein
Format:
This recombinant monoclonal antibody is aseptically packaged and formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.2 - 7.4 with no carrier protein, potassium, calcium or preservatives added. Due to inherent biochemical properties of antibodies, certain products may be prone to precipitation over time. Precipitation may be removed by aseptic centrifugation and/or filtration.
Formulation:
This recombinant monoclonal antibody is aseptically packaged and formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.2 - 7.4 with no carrier protein, potassium, calcium or preservatives added. Due to inherent biochemical properties of antibodies, certain products may be prone to precipitation over time. Precipitation may be removed by aseptic centrifugation and/or filtration.
Immunogen:
Sequenced from human survivors of Sin Nombre.
Long Description:
Hantavirus is an enveloped, negative-sensed, single-stranded RNA virus in the bunyavirus family1. ?New World? hantaviruses (NWH) are found in the Americas and may cause hantavirus pulmonary syndrome (HPS)2. ?Old World? hantaviruses (OWH) are found mostly in Europe and Asia and may cause hemorrhagic fever with renal syndrome. Each hantavirus serotype has a specific rodent host species and infection is spread by aerosolized urine, feces, saliva, or by rodent bites. Sin Nombre Virus (SNV), a NWH first isolated from rodents in the Southwestern United States, infects with a mortality rate of 50%1. The probability of survival for Syrian hamsters infected with SNV significantly increases when treated postinfection with the monoclonal antibody (mAb) SNV-533.
Purity:
?95% monomer by analytical SEC
Target:
Sin Nombre Virus
References
1. Centers for Disease Control and Prevention, National Center for Emerging and Zoonotic Infectious Diseases (NCEZID), Division of High-Consequence Pathogens and Pathology (DHCPP), Link Text
2. Centers for Disease Control and Prevention, National Center for Emerging and Zoonotic Infectious Diseases (NCEZID), Division of High-Consequence Pathogens and Pathology (DHCPP), Link Text
3. Engdahl TB, Kuzmina NA, Ronk AJ, et al. Cell Rep. 35(5):109086. 2021.
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