Anti-Dengue Virus (Clone: DENV-2D22)
| Code | Size | Price |
|---|
| LEI-LT562-250ug | 250 ug | £231.00 |
Quantity:
| LEI-LT562-1.0mg | 1.0 mg | £410.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Virus
Antibody Isotype: Human IgG1
Antibody Clonality: Monoclonal
Antibody Clone: DENV-2D22
Regulatory Status: RUO
Target Species:
- Dengue Virus (DENV)
- Virus
Applications:
- Dot Blot
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Neutralisation
Shipping:
Blue Ice
Storage:
Functional grade preclinical antibodies may be stored sterile as received at 2-8°C for up to one year. For longer term storage aseptically aliquot in working volumes without diluting and store at ? -70°C. Avoid Repeated Freeze Thaw Cycles.
Further Information
Concentration:
? 5.0 mg/ml
Conjugate/Tag/Label:
Purified No Carrier Protein
Format:
This recombinant monoclonal antibody is aseptically packaged and formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.2 - 7.4 with no carrier protein, potassium, calcium or preservatives added. Due to inherent biochemical properties of antibodies, certain products may be prone to precipitation over time. Precipitation may be removed by aseptic centrifugation and/or filtration.
Formulation:
This recombinant monoclonal antibody is aseptically packaged and formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.2 - 7.4 with no carrier protein, potassium, calcium or preservatives added. Due to inherent biochemical properties of antibodies, certain products may be prone to precipitation over time. Precipitation may be removed by aseptic centrifugation and/or filtration.
Immunogen:
Sequenced from human survivors of who had experienced a DENV infection during travel to an endemic region.
Long Description:
Dengue virus (DENV) is the most common insect-transmitted virus to target humans, with an estimated 390 million infections annually1. DENVs are members of the Flaviviridae family and can be divided into four closely related but antigenically distinct serotypes2. They encode a single-stranded positive sense RNA genome and display 180 copies of envelope (E) glycoprotein and premembrane/membrane (prM/M) proteins. E glycoprotein is comprised of three structural domains, DI, DII, and DIII, and exists as a homodimer in the pre-fusion state on the mature virus particle. E undergoes multiple conformation changes during maturation and fusion.
Purity:
?95% monomer by analytical SEC
Target:
Dengue Virus
References
1. Smith SA, de Alwis AR, Kose N, et al. mBio. 4(6):e00873-13. 2013.
2. Lecouturier V, Berry C, Saulnier A, et al. Vaccine. 37(32):4601-4609. 2019.
3. de Alwis R, Smith SA, Olivarez NP, et al. Proc Natl Acad Sci U S A. 109(19):7439-44. 2012.
4. Smith SA, Zhou Y, Olivarez NP, et al. J Virol. 86(5):2665-2675. 2012.
5. Fibriansah G, Ibarra KD, Ng TS, et al. Science. 349(6243):88-91. 2015.
6. Gallichotte EN, Widman DG, Yount BL, et al. mBio. 6(5):e01461-15. 2015.
7. Tuan Vu T, Clapham H, Huynh VTT, et al. PLoS Negl Trop Dis. 13(11):e0007142. 2019.
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