Anti-Ross River Virus (Clone: RRV-12)
| Code | Size | Price |
|---|
| LEI-LT574-250ug | 250 ug | £231.00 |
Quantity:
| LEI-LT574-1.0mg | 1.0 mg | £410.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Virus
Antibody Isotype: Human IgG1
Antibody Clonality: Monoclonal
Antibody Clone: RRV-12
Regulatory Status: RUO
Target Species:
- Ross River Virus
- Virus
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Neutralisation
Shipping:
Blue Ice
Storage:
Functional grade preclinical antibodies may be stored sterile as received at 2-8°C for up to one year. For longer term storage aseptically aliquot in working volumes without diluting and store at ? -70°C. Avoid Repeated Freeze Thaw Cycles.
Further Information
Antigen Distribution:
RoE2 is expressed on the surface of RRV.
Concentration:
? 5.0 mg/ml
Conjugate/Tag/Label:
Purified No Carrier Protein
Format:
This recombinant monoclonal antibody is aseptically packaged and formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.2 - 7.4 with no carrier protein, potassium, calcium or preservatives added. Due to inherent biochemical properties of antibodies, certain products may be prone to precipitation over time. Precipitation may be removed by aseptic centrifugation and/or filtration.
Formulation:
This recombinant monoclonal antibody is aseptically packaged and formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.2 - 7.4 with no carrier protein, potassium, calcium or preservatives added. Due to inherent biochemical properties of antibodies, certain products may be prone to precipitation over time. Precipitation may be removed by aseptic centrifugation and/or filtration.
Immunogen:
A panel of human mAbs, including clone RRV-12, were sequenced from the peripheral blood mononuclear cells of two donors who were naturally infected with RRV1.
Long Description:
Ross River Virus (RRV) is a mosquito-borne, positive sense, single-stranded virus endemic to Australia and Papua New Guinea that belongs to the arthritogenic group of alphaviruses1. The mature glycoprotein is composed of E1 and E2 envelope proteins in a heterodimer, expressed as a trimeric spike on the virus surface 2.
B cells were transformed with Epstein-Barr virus and then screened by direct virus binding ELISA. Hybridoma lines were established and mAbs were purified by single-cell flow cytometric sorting.
Clone RRV-12 is of the IgG1 isotype and is capable of binding and incompletely neutralizing prototype strain RRV T48 in a focus reduction neutralization test1.
Purity:
?95% monomer by analytical SEC
Target:
Ross River Virus
References
1. Powell LA, Fox JM, Kose N, et al. PLoS Pathog. 16(5):e1008517. 2020.
2. Snyder AJ, Mukhopadhyay S. J Virol. 86(24):13609-20. 2012.
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| Anti-Ross River Virus (Clone: RRV-86) | LEI-LT573 | Leinco Technologies | Summary Details | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||