Anti-Influenza A, HA (Clone: Flu-5J8)
| Code | Size | Price |
|---|
| LEI-LT579-250ug | 250 ug | £231.00 |
Quantity:
| LEI-LT579-1.0mg | 1.0 mg | £410.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Virus
Antibody Isotype: Human IgG1
Antibody Clonality: Monoclonal
Antibody Clone: Flu-5J8
Regulatory Status: RUO
Target Species:
- Influenza virus
- Virus
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Flow Cytometry
- Neutralisation
Shipping:
Blue Ice
Storage:
Functional grade preclinical antibodies may be stored sterile as received at 2-8°C for up to one year. For longer term storage aseptically aliquot in working volumes without diluting and store at ? -70°C. Avoid Repeated Freeze Thaw Cycles.
Further Information
Antigen Distribution:
HA is on the viral surface.
Concentration:
? 5.0 mg/ml
Conjugate/Tag/Label:
Purified No Carrier Protein
Format:
This recombinant monoclonal antibody is aseptically packaged and formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.2 - 7.4 with no carrier protein, potassium, calcium or preservatives added. Due to inherent biochemical properties of antibodies, certain products may be prone to precipitation over time. Precipitation may be removed by aseptic centrifugation and/or filtration.
Formulation:
This recombinant monoclonal antibody is aseptically packaged and formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.2 - 7.4 with no carrier protein, potassium, calcium or preservatives added. Due to inherent biochemical properties of antibodies, certain products may be prone to precipitation over time. Precipitation may be removed by aseptic centrifugation and/or filtration.
Immunogen:
Peripheral blood mononuclear cells were isolated from a healthy human subject and was screened by ELISA against a panel of recombinant soluble HA proteins
Long Description:
Hemagglutinin (HA) is a glycoprotein on the Influenza A (IAV) viral surface1. HA consists of two domains: an antigenically variable head and a more conserved stem. There are 18 HA subtypes. Neutralizing antibodies targeting the head domain are typically restricted to within subtype, while antibodies targeting the stem offer broader protection. In contrast, Flu-5J8 targets the HA globular head and offers broad protection2.
Flu-5J8 inhibits all 1918 to 1977 H1N1 strains tested plus the pandemic 2009 strain but not the seasonal H1N1 strains from 1999 or 2007.
Purity:
?95% monomer by analytical SEC
Target:
Flu A, HA
References
1. Bangaru S, Lang S, Schotsaert M, et al. Cell. 177(5):1136-1152.e18. 2019.
2. Krause JC, Tsibane T, Tumpey TM, et al. J Virol.85(20):10905-10908. 2011.
3. Hong M, Lee PS, Hoffman RM, et al. J Virol. 87(22):12471-12480. 2013.
4. Lee J, Boutz DR, Chromikova V, et al. Nat Med. 22(12):1456-1464. 2016.
5. Gilchuk P, Bombardi RG, Erasmus JH, et al. Nat Biomed Eng. 4(11):1030-1043. 2020.
6. Zost SJ, Dong J, Gilchuk IM, et al. J Clin Invest. 2;131(15):e146791. 2021.
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