Anti-Mouse/Rat CD71 - APC
| Code | Size | Price |
|---|
| LEI-C869-50ug | 50 ug | £191.00 |
Quantity:
| LEI-C869-100ug | 100 ug | £219.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Mouse
Antibody Isotype: IgG2a κ
Antibody Clonality: Monoclonal
Antibody Clone: OX-26
Regulatory Status: RUO
Target Species:
- Mouse
- Rat
Application: Flow Cytometry
Shipping:
2-8°C
Storage:
This Allophyc°Cyanin (APC) conjugate is stable when stored at 2-8°C. Do not freeze.
Further Information
Antigen Distribution:
CD71 is expressed on the surface of proliferating cells, reticulocytes, and erythroid precursors.
Concentration:
0.2 mg/ml
Conjugate/Tag/Label:
Allophycocyanin (APC)
Format:
This Allophycocyanin (APC) conjugate is formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.4, 1% BSA and 0.09% sodium azide as a preservative.
Formulation:
This Allophycocyanin (APC) conjugate is formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.4, 1% BSA and 0.09% sodium azide as a preservative.
Immunogen:
PHA-activated rat lymph node cells
Long Description:
CD71 is a transferrin receptor on the cell surface that mediates the uptake of transferrin-iron complexes, thereby mediating cellular proliferation1. CD71 is a homodimeric glycoprotein containing 760 amino acids and it binds to diferric transferrin2. Binding by diferric transfferin causes CD71 to be internalized, and diferric iron is subsequently released3. CD71 is highly expressed on malignant cells, as iron uptake is necessary for aberrant cell proliferation4.
Target:
CD71
References
1. Aisen P. Int J Biochem Cell Biol. Nov;36(11):2137-43. 2004.
2. Lawrence CM, Ray S, Babyonyshev M, et. al. Science. Oct 22;286(5440):779-82. 1999.
3. Marsee DK, Pinkus GS, Yu H. Am J Clin Pathol. Sep;134(3):429-35. 2010.
4. Candelaria PV, Leoh LS, Penichet ML, Daniels-Wells TR. Front Immunol. Mar 17;12:607692. 2021
5. Jim?nez E, Saced?n R, Vicente A, et. al. J Immunol. May 15;168(10):5005-13. 2002.
6. Fabriek BO, Polfliet MM, Vloet RP, et. al. Blood. Jun 15;109(12):5223-9. 2007.
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