Caspase-9 inhibitor Z-LEHD-FMK
Code | Size | Price |
---|
MBL-4810-510 | 20 ul | £161.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
4°C
Storage:
-20°C
Documents
Further Information
Background:
Caspase is a member of the cysteine
aspartic acid-specific protease family, which is activated
by a variety of signals of death receptor ligation, DNA
damages, serum starvation and stresses etc. Active caspase
recognizes a lot of several molecules as substrates to
cleave them, occurring to biological events corresponding
to the apoptosis. For example, ICAD (inhibitor of
caspase-activated deoxyrubonucrease) is inactivated and
CAD (caspase-activated deoxyrubonucrease) is indirectly
activated by caspase-3, and it is related to chromatin
fragmentation for nucleosome units. Caspase recognizes
several structural proteins as a substrate to cleave them,
and the cleavage is associated with the unique apoptosis
cell morphology of chromatin condensation, nucleus
fragmentation and cytoplasmic integrity. Tetra peptide
sequence ?LEHD? is preferentially recognized by
caspase-9. Z-LEHD-FMK is an irreversible and cell
permeable powerful inhibitor for caspase-9.
Gene IDs:
Human: 836 Mouse: 12367
Target:
Caspase-9
References
1) Notoya K., et al., J Immunol., 165, 3402-3410 (2000)
2) Ozoren N., et al., Cancer Res., 60, 6259-65 (2000)