Anti-CD117 (c-Kit) (Human) pAb

ICC, IHC

c-Kit, also known as stem cell factor receptor, steel factor receptor or CD117 is classified as a type III receptor tyrosine kinase (RTK) belonging to the platelet-derived growth factor receptor subfamily. Binding of stem cell factor (SCF), known as c-Kit ligand to c-Kit, initiates autophosphorylation of the receptor, subsequently leading to promotes a signal transduction cascade through Ras-Raf-MAP kinase cascade, phosphatidylinositol- 3-kinase, src family kinases, and JAK/STAT pathways. The roles of c-Kit include maturation of hematopoietic and primordial germ cells precursors and melanocytes during embryonic development. In acute myeloid leukemia (AML), c-Kit has been proposed to play a functional role, and becomes target molecule for drug development.

Unlabeled

In 20 mM HEPES/1% BSA/0.135 M NaCl/0.1% sodium azide

Human: 3815 Mouse: 16590

Synthetic peptide C-terminal portion of c-kit gene product carrier protein binding (K963)

This antibody reacts with c-Kit on Immunohistochemistry.

3 years

This antibody was purified from rabbit serum using the synthesized peptides (C-terminal of c-Kit gene product; K963) coupled protein A agarose column. The rabbit was immunized with carrier protein conjugated synthesized peptides (K963).

KIT, PBT, SCFR