Anti-SLC7A5 (LAT1) (Human) pAb

WB - 1:1000 (chemiluminescence detection system) IHC - 1:1000 (Heat treatment required for paraffin)

SLC7A5, L-type amino acid transporter 1 (LAT1), forms as a heterodimeric complex with the heavy chain of the cell surface antigen 4F2 (4F2hc/CD98). It transports neutral amino acids, most of which are essential amino acids across blood brain barrier. L-dopa, which is commonly used to treat Parkinson?s disease, also enters the brain the LAT1/CD98 complex. In addition, tumors with increased expression of SLC7A5 have been reported. Increased uptake of amino acids through SLC7A5 may facilitate tumor cell growth and survival.

100 ul volume of PBS containing 50% glycerol, pH 7.2. No preservative is contained.

Human: 8140 Mouse: 20539

Synthetic peptide derived from human SLC7A5

This antibody can be used to stain endogenous antigen in paraffin embedded human tissues including brain by immunohistochemistry. The reactivity of this antibody has been confirmed by Western blotting to detect the full-length of human SLC7A5 transiently expressed in HEK 293T cells.

1 year

This antibody was affinity purified from rabbit serum. The rabbit was immunized with a synthetic peptide derived from human SLC7A5.

SLC7A5/LAT1