Anti-SLC4A1 (AE1) (Human) pAb
| Code | Size | Price |
|---|
| MBL-BMP012 | 100 ul | £323.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Applications:
- Immunohistochemistry (IHC)
- Western Blot (WB)
Shipping:
4°C
Storage:
-20°C
Documents
Further Information
Applications:
WB - 1:1000 (chemiluminescence detection system) IHC - 1:1000 (Heat treatment required for paraffin)
Background:
SLC4A1/AE1/Band3/CD233, a member of the anion exchanger family, is the major glycoprotein of the erythrocyte membrane. SLC4A1 has an important role for the high rate exchange of chloride by bicarbonate ion during carbon dioxide transport by erythrocytes. Defective mutations of SLC4A1 gene have been reported to cause either the erythroid disorders including spherocytic hemolytic anaemia or ovalocytosis, or distal renal tubular acidosis. One SLC4A1 null human is also known with very severe anemia and nephrocalcinosis.
Formulation:
100 ul volume of PBS containing 50% glycerol, pH 7.2. No preservative is contained.
Gene IDs:
Human: 6521 Mouse: 20533
Immunogen Translated:
Synthetic peptide derived from human SLC4A1
Reactivity:
This antibody can be used to stain erythrocytes in paraffin embedded human tissues by immunohistochemistry. The reactivity of this antibody has been confirmed by Western blotting to detect the full-length of human SLC4A1 transiently expressed in HEK 293T cells
Shelf Life:
1 year
Source:
This antibody was affinity purified from rabbit serum. The rabbit was immunized with a synthetic peptide derived from human SLC4A1.
Target:
SLC4A1/AE1
References
1) Shayakul, C., and Alper, S. L., Clin. Exp. Nephrol. 8, 1-11 (2004)
2) Karet, F. E., et al., PNAS 95, 6337-6342 (1998)
3) Lux, S. E., et al., PNAS 86, 9089-9093 (1989)
4) Palumbo, A. P., et al., Am. J. Hum. Genet. 39, 307-316 (1986)