Anti-SLC7A9 (B0,+AT) (Human) pAb

WB - 1:1000 (chemiluminescence detection system) FCM - 1:1000 ICC - 1:1000 IHC - 1:5,000 Heat treatment is necessary for staining paraffin embedded sections. Autoclave; 125 o C for 5 minutes in 10 mM citrate buffer containing 0.05% Tween-20 (pH 6.0).

SLC7A9, also known as B0,+- type amino acid transporter (B0,+AT), is a member of the cationic amino acid transporter/glycoprotein-associated family, and it functions as a heterodimer with the amino acid transport protein SLC3A1/rBAT. The SLC7A9 protein is predominantly distributed in the kidney, small intestine, liver, and placenta. Defective mutations in the SLC7A9 and/or SLC3A1 gene cause cystinuria, which is characterized by impaired transport of cystine and dibasic amino acids through the epithelial cells of the renal tubule and gastrointestinal tract; this results in the formation of calculi due to cystine precipitation in the urinary tract, leading to obstruction, infections, and ultimately, renal insufficiency.

50 ul volume of PBS containing50% glycerol, pH 7.2. No preservative is contained.

Human: 11136 Mouse: 30962

Synthetic peptide derived from human SLC7A9

This antibody can be used to stain endogenous antigen in paraffin embedded human tissues including the small intestine and kidney by Immunohistochemistry. The reactivity has been confirmed by Western blotting, Immunocytochemistry and intracellular Flow cytometry to detect the full length of human SLC7A9 transiently expressed in HEK 293T cells.

1 year

This antibody was affinity purified from rabbit serum. The rabbit was immunized with a synthetic peptide derived from human SLC7A9.

SLC7A9/B0,+AT