Anti-SLC16A2 (MCT8) (Human) pAb
Code | Size | Price |
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MBL-BMP031 | 50 ul | £323.00 |
Quantity:
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Overview
Host Type: Rabbit
Antibody Isotype: IgG
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Applications:
- Flow Cytometry
- Immunocytochemistry (ICC)
- Immunohistochemistry (IHC)
- Western Blot (WB)
Shipping:
4°C
Storage:
-20°C
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Further Information
Alternative Names:
MCT8
Applications:
WB - 1:1000 (chemiluminescence detection system) FCM - 1:200 ICC - 1:200 IHC - 1:1000 (Heat treatment required for paraffin)
Background:
SLC16A2, also known as
monocarboxylate transporter 8 (MCT8), is responsible for
the transport of thyroid hormone 3 (T3) into the nerve cells
in the developing brain. After T3 is transported into a nerve
cell, it interacts with intranuc
lear receptors, which activate
or inhibit the expression of specific genes that are related to
cell migration, dendrite formation, and synapse
development. SLC16A2 is also distributed in several
organs such as the liver, heart, brain, thymus, intestine,
ovary, prostate, pancreas, and placenta. A mutation in the
SLC16A2 gene inhibits the transport of T3 into the brain
and results in the Allan-Herndon-Dudley syndrome, which
is characterized by severe intellectual disability and
impaired movement.
Formulation:
50 ul volume of PBS containing50% glycerol, pH 7.2. No preservative is contained.
Gene IDs:
Human: 6567 Mouse: 20502
Immunogen Translated:
Synthetic peptide derived from human SLC16A2
Reactivity:
This antibody can be used to stain
endogenous antigen in paraffin embedded human tissues
including the pancreas, cerebellum and small intestine by
Immunohistochemistry. The reactivity has been confirmed
by Western blotting, Im
munocytochemistry, and
intracellular Flow cytometry to detect the full length of
human SLC16A2 transiently expressed in HEK 293T cells.
Shelf Life:
1 year
Source:
This antibody was affinity purified from rabbit
serum. The rabbit was immunized with a synthetic peptide
derived from human SLC16A2.
Target:
SLC16A2
References
?1) Schwartz, C. E., et al., Am. J. Hum. Genet. 77, 41-53 (2005)
2) Lafreni?re, R. G., et al., Hum. Mol. Genet. 3, 1133-1139 (1994)