Anti-SLC40A1 (FPN1) (Human) pAb

Product Code: MBL-BMP033

Supplier: MBL

Code	Size	Price

MBL-BMP033

50 uL

£323.00

Quantity:

Prices exclude any Taxes / VAT

Overview

Host Type: Rabbit

Antibody Isotype: IgG

Antibody Clonality: Polyclonal

Regulatory Status: RUO

Target Species: Human

Applications:

Flow Cytometry
Immunocytochemistry (ICC)
Immunohistochemistry (IHC)
Western Blot (WB)

Shipping:

4°C

Storage:

-20°C

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Documents

Datasheet

Further Information

Alternative Names:

ferroportin 1

Applications:

WB - 1:1000 (chemiluminescence detection system) FCM - 1:1000 ICC - 1:1000 IHC - 1:5000 (Heat treatment required for paraffin)

Background:

SLC40A1, also known as ferroportin 1, belongs to the iron-regulated transporter family and absorbs iron from the diet into the bloodstream through the small intestine. The absorbed iron binds to transferrin in the blood and is then carried to tissues and organs throughout the body. SLC40A1 also transports iron out of reticuloendothelial cells, which are phagocytic immune cells present in the liver, spleen, and bone marrow. Mutations in the SLC40A1 gene cause hemochromatosis, which is characterized by impaired iron regulation and disorders associated with ir on deficiency or overload.

Formulation:

50 ul volume of PBS containing50% glycerol, pH 7.2. No preservative is contained.

Gene IDs:

Human: 30061 Mouse: 53945

Immunogen Translated:

Synthetic peptide derived from human SLC40A1

Reactivity:

This antibody can be used to stain endogenous antigen in paraffin embedded human tissues including kidney by Immunohistochemistry. The reactivity has been confirmed by Western blotting, Immunocytochemistry, and intr acellular Flow cytometry to detect the full length of human SLC40A1 transiently expressed in HEK 293T cells.

Shelf Life:

1 year

Source:

This antibody was affinity purified from rabbit serum. The rabbit was immunized with a synthetic peptide derived from human SLC40A1.

Target:

SLC40A1

References

?1) Zohn, I. E., et al., Blood 109, 4174-4180 (2007) 2) Donovan, A., et al., Cell Metab. 1, 191-200 (2005) 3) Domenico, I. D., et al., PNAS 102, 8955-8960 (2005) 4) Montosi, G., et al., J. Clin. Invest. 108, 619-623 (2001) 5) Donovan, A., et al., Nature 403, 776-781 (2000) 6) McKie, A. T., et al., Mol. Cell 5, 299-309 (2000)