Anti-SLC7A8 (LAT2) (Human) pAb

LAT2

WB - 1:1000 (chemiluminescence detection system) FCM - 1:200 ICC - 1:200 IHC - 1:1000 (Heat treatment required for paraffin)

SLC7A8, also called L -type amino acid transporter 2 (LAT2), forms a heterodimeric complex with the heavy chain of th e cell surface antigen SLC3A2 (4F2hc/CD98). It transports neutral amino acids, most of which are essential amino acids. L -Dopa, which is commonly used to treat Parkinson?s disease, can enter the brain as either the SLC7A8 (LAT2)/SLC3A2 complex or as its homologue the SLC7A7 (LAT1)/SLC3A2 complex. Furthermore, SLC7A8 is highly expressed in the epithelial proximal tubule cells in the kidney; this suggests its role in renal reabsorption of neutral amino acids.

50 ul volume of PBS containing50% glycerol, pH 7.2. No preservative is contained.

Human: 23428 Mouse: 50934

Synthetic peptide derived from human SLC7A8

This antibody can be used to stain endogenous antigen in paraffin embedded human tissues including kidney and pancreas by Immunohistochemistry. The reactivity has been confirmed by Western blotting, Immunocytochemistry, and intr acellular Flow cytometry to detect the full length of human SLC7A8 transiently expressed in HEK 293T cells.

1 year

This antibody was affinity purified from rabbit serum. The rabbit was immunized with a synthetic peptide derived from human SLC7A8.

SLC7A8