Anti-SLC18A3 (VAChT) (Human) pAb

FCM - 1:200 IHC - 1:5000 (Heat treatment required for paraffin)

SLC18A3, also known as the vesicular acetylcholine transpor ter (VAChT), belongs to the family of vesicular monoamine transporters (VMATs). It is localized to the cell membranes in the peripheral and central cholinergic nervous systems and transports the neurotransmitter acetylcholine, which is synthesized by the enzyme choline acetyltransf erase from the compounds choline and acetyl-CoA, into th e synaptic secretory vesicles. The transport of acetylcholine oc curs via a proton gradient established by vacuolar ATPase. In addition, the SLC18A3 gene is located within the first intron of the choline acetyltransferase gene, and pr otein kinase A appears to regulate transcription at this cholinergic gene locus.

50 ul volume of PBS containing50% glycerol, pH 7.2. No preservative is contained.

Human: 6572 Mouse: 20508

Synthetic peptide derived from human SLC18A3

This antibody can be used to stain endogenous antigen in paraffin embedded human tissues including kidney by Immunohistochemistry. The reactivity has been confirmed by intracellular Flow cytometry to detect the full length of human SLC18A3 transiently expressed in HEK 293T cells.

1 year

This antibody was affinity purified from rabbit serum. The rabbit was immunized with a synthetic peptide derived from human SLC18A3.

SLC18A3/VAChT