Anti-SLC22A12 (URAT1) (Human) pAb

Product Code: MBL-BMP064

Supplier: MBL

Code	Size	Price

MBL-BMP064

50 ul

£323.00

Quantity:

Prices exclude any Taxes / VAT

Overview

Host Type: Rabbit

Antibody Isotype: IgG

Antibody Clonality: Polyclonal

Regulatory Status: RUO

Target Species: Human

Applications:

Flow Cytometry
Immunocytochemistry (ICC)
Immunohistochemistry (IHC)

Shipping:

4°C

Storage:

-20°C

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Documents

Datasheet

Further Information

Alternative Names:

urate transporter 1, URAT1

Applications:

FCM - 1:1000 ICC - 1:1000 IHC - 1:5000 (Heat treatment required for paraffin)

Background:

SLC22A12, also known as urate transporter 1 (URAT1), is a member of the organic cation/anion/zwitterion transporter family. This transporter is present on the epithelial cells of proximal tubules in the renal cortex and mediates urate uptake. Gene mutations or functional defects of URAT1 have been identified in patients with renal hypouricemia, which is characterized by low serum urate levels. Disorders associated with this condition include uric acid urolithiasis; hematuria; hypercalcemia; or occasionally, exercise-induced acute renal failure.

Formulation:

50 ul volume of PBS containing50% glycerol, pH 7.2. No preservative is contained.

Gene IDs:

Human: 116085 Mouse: 20521

Immunogen Translated:

Synthetic peptide derived from human SLC22A12

Reactivity:

This antibody can be used to stain endogenous antigen in paraffin embedded human tissues including the kidney by Immunohistochemistry. The reactivity has been confirmed by Immunocytochemistry and intracellular Flow cytometry to detect the full length of human SLC22A12 transiently expressed in HEK 293T cells.

Shelf Life:

1 year

Source:

This antibody was affinity purified from rabbit serum. The rabbit was immunized with a synthetic peptide derived from human SLC22A12.

Target:

SLC22A12/URAT1

References

1) Ichida, K., et al., Clin Genet 74, 243-251 (2008) 2) Thangaraju, M., et al., J. Biol. Chem. 281, 26769-26773 (2006) 3) Wakida, N., et al., J. Clin. Endocrinol. Metab. 90, 2169-2174 (2005) 4) Tanaka, M., et al., Am. J. Kidney Dis. 42, 1287-1292 (2003) 5) Enomoto, A., et al., Nature 417, 447-452 (2002)